EK1393

Human NT-proBNP ELISA Kit 检测试剂盒（酶联免疫吸附法）

¥1,600.00 – ¥2,650.00

分子靶点：NPPB, preproBNP, proBNP
种属：人 (Human)
样本类型：血清，血浆，细胞培养上清及其他生物学样本
检测样本体积：10 μL
灵敏度：4.56 pg/mL
检测范围：31.25 pg/mL - 2000 pg/mL
回收率：91% - 119%

在售SKU:70-EK1393-48, 70-EK1393-96, EK1393

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文章目录[隐藏]

NPPB 分子靶点信息概述
NPPB 分子靶点综述
NPPB, natriuretic peptide B 分子靶点种属信息
- 人 Human NPPB 分子靶点信息
- 人 Human NPPB靶点分子功能（预测）

商品名	Human NT-proBNP ELISA Kit 检测试剂盒（酶联免疫吸附法）
检测方法	双抗夹心法
精密度	板内变异系数：4.1% - 6.0%；板间变异系数：3.7% - 4.1 %
样本类型	血清、血浆，细胞培养上清及其他生物学样本
检测样本体积	10 μL
灵敏度	4.56 pg/mL
检测范围	31.25 pg/mL - 2000 pg/mL
回收率	91% - 119%
平均回收率	1.06
板式	96孔板，可拆
保存	试剂盒未拆开，4℃保存。已拆开，标准品-20℃保存，其它4℃保存。
运输条件	4℃蓝冰运输
组分	包被鼠抗人NT-proBNP 捕获抗体的96孔聚苯乙烯酶标板 Human NT-proBNP冻干标准品 Human NT-proBNP检测抗体 Streptavidin-HRP 检测缓冲液(10×) 底物(TMB) 终止液洗液(20×) 封板膜标准品稀释液

检测原理：本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性捕获抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本和生物素化的检测抗体，经过孵育，样本中存在的待测物质与捕获抗体和检测抗体结合。洗涤去除未结合的物质后，加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中待测物质的浓度成正比。加入终止液终止反应，在 450 nm 波长(参考波长 570 - 630 nm)测定吸光度值。

Human NT-proBNP ELISA Kit 检测试剂盒（酶联免疫吸附法） - 标准曲线 — 标准曲线

NPPB 分子靶点信息概述

分子名：NPPB, natriuretic peptide B
基因家族：Neuropeptides
曾用名：natriuretic peptide precursor B
全称：natriuretic peptide precursor B

NPPB 分子靶点综述

脑型利钠肽(Brain-type Natriuretic Peptide, BNP)是一种非糖基化肽，主要由心室肌细胞产生，属于利钠肽家族。12 kDa BNP 前体蛋白水解裂解产生 N 端 proBNP (NT-proBNP)和成熟的 BNP。血浆 NT-proBNP 是充血性心力衰竭的标志，而成熟 BNP (AA 103 - 134)促进血管扩张和液体和钠的排泄。人类 BNP 前体与小鼠和猪 BNP 前体的 AA 序列同源性分别为29%和 51%。 BNP 是一种心脏激素，可能作为心脏旁分泌抗纤维化因子。通过利钠、利尿、血管舒张和抑制肾素和醛固酮分泌，也在心血管内稳态中发挥关键作用。特异性结合和刺激 NPR1 受体的 cGMP 产生。与清除受体 NPR3 结合。应用于肿瘤，心血管疾病等。

NPPB, natriuretic peptide B 分子靶点种属信息

人 Human

人 Human NPPB 分子靶点信息

分子名：NPPB, natriuretic peptide B
别称：
- BNP
- brain natriuretic factor prohormone
- brain type natriuretic peptide
- gamma-brain natriuretic peptide
- Iso-ANP
- natriuretic peptide precursor B
- natriuretic peptides B
- natriuretic protein
- preproBNP
- proBNP
基因序列：NCBI_Gene: 4879
蛋白序列：UniProtKB: P16860

人 Human NPPB靶点分子功能（预测）

Enables hormone receptor binding activity. Involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; killing of cells of another organism; and receptor guanylyl cyclase signaling pathway. Part of protein-containing complex. Implicated in atherosclerosis; hypertension; myocardial infarction; obesity; and systolic heart failure. Biomarker of several diseases, including Kawasaki disease; artery disease (multiple); diabetes mellitus (multiple); heart disease (multiple); and kidney failure (multiple).