论文分享 | 24.2分!聚多巴胺如何促进癌症光热免疫治疗?

  • Post category:ELISA检测
  • Post views:228 次访问

文章目录[隐藏]

2024年4月26日,武汉大学一研究团队在Materials TodayIF=24.2)在线发表题为“Polydopamine-armed microalgal oxygenerator targeting the hypoxia-adenosine axis to boost cancer photothermal immunotherapy”的研究论文,此论文使用了联科生物Mouse IFN-γ ELISA Kit(货号:EK280),Mouse TNF-α ELISA Kit(货号:EK282),Mouse IL-6 ELISA Kit(货号:EK206)和Mouse IL-10 ELISA Kit(货号:EK210)4种检测试剂盒。

Fig.1 (f) IFN-γ, (g) TNF-α, (h) IL-6 and (i) IL-10 within tumors (n= 3). Tumors were collected at the sixth day for flowcytometric analysis after different treatments. Representative flow cytometric analysis images (left) and relative quantification analysis (right) of immune cellsas shown. G1, PBS; G2, PTA; G3, PTA + 660; G4, PTA + 808; G5, PTA + 660 + 808.

研究团队开发了一种光热微藻系统(PTA,以解决肿瘤微环境中缺氧导致的免疫抑制问题:

①使用了一种名为Chlorella sorokinianaC. soro)的微藻,通过在其表面涂覆一种名为聚多巴胺(PDA的光热剂,构建了PTA

②这种微藻系统能够在660纳米的光照下原位产生氧气,减轻肿瘤缺氧情况,从而降低腺苷水平,逆转肿瘤微环境中的免疫抑制。

③这种改变的肿瘤微环境促进了光热疗法(PTT)诱导的抗肿瘤免疫活性,这是通过808纳米的光照下C. soro表面的PDA层实现的。

④在4T1肿瘤小鼠模型中,PTA显著减弱了肿瘤微环境中的免疫抑制,引发了强烈的抗肿瘤免疫反应,抑制了肿瘤生长。

总之,该策略突出了利用活的光合微藻作为制氧机来促进癌症光热免疫治疗的潜力。

Fig2.A microalgal oxygenerator (PTA) was developed by surface coating microalgae with the photothermal agent polydopamine. The PTA is capable of generating O2 in situ within the tumor through photosynthesis. This process effectively targets the hypoxia-adenosine axis, thereby reducing immunosuppression. The modification of the tumor microenvironment promotes antitumor immunity triggered by photothermal therapy and significantly improves antitumor efficiency.

联科生物产品助力科研

货号:EK206

产品名:Mouse IL-6 ELISA Kit

部分引用文献:

An injectable liposome-anchored teriparatide incorporated gallic acid-grafted gelatin hydrogel for osteoarthritis treatment 

货号:EK280

产品名:Mouse IFN-γ ELISA Kit

部分引用文献:

Multifunctional biomimetic nanoplatform based on photodynamic therapy and DNA repairintervention for the synergistic treatment of breast cancer 

货号:EK282

产品名:Mouse TNF-α ELISA Kit

部分引用文献:

An injectable liposome-anchored teriparatide incorporated gallic acid-grafted gelatin hydrogel for osteoarthritis treatment 

货号:EK210

产品名:Mouse IL-10 ELISA Kit

部分引用文献:

Camouflaging attenuated Salmonella by cryo-shocked macrophages for tumor-targeted therapy

引用文献:

Zhang C, Han Z Y, Chen K W, et al. Polydopamine-armed microalgal oxygenerator targeting the hypoxia-adenosine axis to boost cancer photothermal immunotherapy[J]. Materials Today, 2024.

原文链接:

https://www.sciencedirect.com/science/article/abs/pii/S1369702124000580