NPPB 靶点信息

NPPB 分子靶点信息概述

  • 分子名：NPPB, natriuretic peptide B
  • 基因家族：Neuropeptides
  • 曾用名：natriuretic peptide precursor B
  • 全称：natriuretic peptide precursor B

NPPB 分子靶点综述

脑型利钠肽(Brain-type Natriuretic Peptide, BNP)是一种非糖基化肽，主要由心室肌细胞产生，属于利钠肽家族。12 kDa BNP 前体蛋白水解裂解产生 N 端 proBNP (NT-proBNP)和成熟的 BNP。血浆 NT-proBNP 是充血性心力衰竭的标志，而成熟 BNP (AA 103 - 134)促进血管扩张和液体和钠的排泄。人类 BNP 前体与小鼠和猪 BNP 前体的 AA 序列同源性分别为29%和 51%。 BNP 是一种心脏激素，可能作为心脏旁分泌抗纤维化因子。通过利钠、利尿、血管舒张和抑制肾素和醛固酮分泌，也在心血管内稳态中发挥关键作用。特异性结合和刺激 NPR1 受体的 cGMP 产生。与清除受体 NPR3 结合。应用于肿瘤，心血管疾病等。

NPPB, natriuretic peptide B 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human NPPB 分子靶点信息

  • 分子名：NPPB, natriuretic peptide B
  • 别称：
    • BNP
    • brain natriuretic factor prohormone
    • brain type natriuretic peptide
    • gamma-brain natriuretic peptide
    • Iso-ANP
    • natriuretic peptide precursor B
    • natriuretic peptides B
    • natriuretic protein
    • preproBNP
    • proBNP
  • 基因序列：NCBI_Gene: 4879
  • 蛋白序列：UniProtKB: P16860

人 Human NPPB靶点分子功能（预测）

Enables hormone receptor binding activity. Involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; killing of cells of another organism; and receptor guanylyl cyclase signaling pathway. Part of protein-containing complex. Implicated in atherosclerosis; hypertension; myocardial infarction; obesity; and systolic heart failure. Biomarker of several diseases, including Kawasaki disease; artery disease (multiple); diabetes mellitus (multiple); heart disease (multiple); and kidney failure (multiple).

小鼠 Mouse Nppb 分子靶点信息

  • 分子名：Nppb, natriuretic peptide type B
  • 别称：
    • AA408272
    • BNP
    • expressed sequence AA408272
  • 基因序列：NCBI_Gene: 18158
  • 蛋白序列：

    小鼠 Mouse Nppb 靶点分子功能（预测）

    Predicted to enable hormone activity and hormone receptor binding activity. Acts upstream of or within cardiac muscle hypertrophy in response to stress. Predicted to be located in perinuclear region of cytoplasm and transport vesicle. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm; extracellular space; and nucleus. Is expressed in heart; heart atrium; heart left ventricle; heart ventricle; and primitive ventricle. Human ortholog(s) of this gene implicated in atherosclerosis; hypertension; myocardial infarction; obesity; and systolic heart failure. Orthologous to human NPPB (natriuretic peptide B).

大鼠 Rat Nppb 分子靶点信息

  • 分子名：Nppb, natriuretic peptide B
  • 别称：
    • Bnf
    • BNP
    • Brain natriuretic factor
    • brain natriuretic factor prohormone
    • brain natriuretic peptide
    • gamma-brain natriuretic peptide
    • iso-ANP
    • natriuretic peptide precursor B
    • natriuretic peptide precursor type B
    • natriuretic peptides B
    • preproBNP
    • proBNP
  • 基因序列：NCBI_Gene: 25105
  • 蛋白序列：

大鼠 Rat Nppb 靶点分子功能（预测）

Enables hormone activity. Involved in several processes, including cellular response to mechanical stimulus; negative regulation of cell population proliferation; and positive regulation of cGMP-mediated signaling. Located in several cellular components, including extracellular space; perinuclear region of cytoplasm; and transport vesicle. Used to study hypertension; hypertensive heart disease; myocardial infarction; polycystic kidney disease; and proteinuria. Biomarker of several diseases, including artery disease (multiple); heart disease (multiple); hyperhomocysteinemia; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in atherosclerosis; hypertension; myocardial infarction; obesity; and systolic heart failure. Orthologous to human NPPB (natriuretic peptide B).

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