Rat TNF-α High Sensitivity Standard (大鼠肿瘤坏死因子α高敏 标准品)

TNF 分子靶点信息概述

• 分子名：TNF, tumor necrosis factor
• 基因家族：Tumor necrosis factor superfamily
• 别名：TNFSF2; DIF; TNF-alpha
• 曾用名：TNFA
• 全称：TNF superfamily, member 2; tumor necrosis factor (TNF superfamily, member 2)

TNF 分子靶点综述

TNF-α 为单核细胞、巨噬细胞、中性粒细胞、NK 细胞和 CD4+T 细胞产生的 17 kDa 细胞因子。它在免疫应答中具有多种调节功能，还可作为潜在的热原。TNF-α对刺激物(感染因子或组织受损)产生应答后，在全身循环，激活中性粒细胞，改变血管内皮细胞的特性，调控其它组织的代谢活性，以及通过诱导局部凝血作用展现肿瘤杀伤活性。TNF-α 在关节组织和其它组织发生炎症的发病机制具有重要作用。

大鼠 Rat Tnf 分子靶点信息

• 分子名：Tnf, tumor necrosis factor
• 别称：
  • cachectin
  • LOC103694380
  • MGC124630
  • RATTNF
  • TNF-a
  • TNF-alpha
  • Tnfa
  • tumor necrosis factor (TNF superfamily, member 2)
  • tumor necrosis factor alpha
  • tumor necrosis factor ligand superfamily member 2
  • tumor necrosis factor superfamily member 2
  • tumor necrosis factor superfamily, member 2
  • tumor necrosis factor-alpha
  • tumor necrosis factor-like
• 基因序列：NCBI_Gene: 24835
• 蛋白序列：UniProtKB: P16599

大鼠 Rat Tnf 靶点分子功能（预测）

Enables tumor necrosis factor receptor binding activity. Involved in several processes, including positive regulation of cell communication; positive regulation of macromolecule metabolic process; and positive regulation of neuron death. Located in several cellular components, including external side of plasma membrane; extracellular space; and neuronal cell body. Used to study several diseases, including cerebrovascular disease (multiple); liver disease (multiple); peptic esophagitis; perinatal necrotizing enterocolitis; and periventricular leukomalacia. Biomarker of several diseases, including brain disease (multiple); congestive heart failure (multiple); inflammatory bowel disease (multiple); lung disease (multiple); and non-alcoholic fatty liver disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Orthologous to human TNF (tumor necrosis factor).