EK1334

Human Clusterin ELISA Kit检测试剂盒（酶联免疫吸附法）

¥1,600.00 – ¥2,650.00

分子靶点：CLU, Clusterin
种属：人 (Human)
样本类型：血清，血浆，细胞培养上清及其他生物学样本
检测样本体积：100 μL (稀释液)
灵敏度：8.38 pg/mL
检测范围：0.25 ng/mL - 16 ng/mL
回收率：76% - 117%

在售SKU:70-EK1334-48, 70-EK1334-96

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文章目录[隐藏]

CLU 分子靶点信息概述
CLU 分子靶点综述
CLU, clusterin 分子靶点种属信息
- 人 Human CLU 分子靶点信息
- 人 Human CLU靶点分子功能（预测）

商品名	Human Clusterin ELISA Kit 人丛生蛋白(Clusterin)ELISA试剂盒
检测方法	双抗夹心法
精密度	板内变异系数：3.8 % - 6.2%；板间变异系数：6.9 % - 9.0%
样本类型	血清、血浆，细胞培养上清及其他生物学样本
检测样本体积	100 μL (稀释液)
灵敏度	8.38 pg/mL
检测范围	0.25 ng/mL - 16 ng/mL
回收率	76% - 117%
平均回收率	0.98
板式	96孔板，可拆
保存	试剂盒未拆开，4℃保存。已拆开，标准品-20℃保存，其它4℃保存。
运输条件	4℃蓝冰运输
组分	包被小鼠抗人Clusterin捕获抗体的96孔聚苯乙烯酶标板 Human Clusterin冻干标准品 Human Clusterin检测抗体 Streptavidin-HRP 检测缓冲液(10×) 底物(TMB) 终止液洗液(20×) 封板膜标准品稀释液

检测原理：本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人Clusterin抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本和生物素化的检测抗体，经过孵育，样本中存在的Clusterin与固相抗体和检测抗体结合。洗涤去除未结合的物质后，加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中Clusterin的浓度成正比。加入终止液终止反应，在450 nm波长(参考波长570 - 630 nm)测定吸光度值。

Human Clusterin ELISA Kit 人丛生蛋白(Clusterin)ELISA试剂盒 - 标准曲线 — 标准曲线

CLU 分子靶点信息概述

分子名：CLU, clusterin
基因家族：Complement system regulators and receptors; MicroRNA protein coding host genes
别名：SGP-2; SP-40; TRPM-2; KUB1; CLU1; CLU2
曾用名：CLI; APOJ
全称：clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J); complement lysis inhibitor; sulfated glycoprotein 2; testosterone-repressed prostate message 2; apolipoprotein J

CLU 分子靶点综述

丛生蛋白(Clusterin)是 1983 年首次由绵羊睾丸膜体液中分离得到的，是一种普遍存在的、高度保守的异源二聚体硫酸化糖蛋白，该蛋白广泛表达于机体多种组织中，发挥促细胞聚集、调节生殖、组织修复、转运脂类、补体抑制/调节免疫等多种功能。由于其具有广泛、未明机制的各种功能，因而具有多种命名，例如载脂蛋白 J、硫酸糖蛋白 2 (SGP-2)、TRPM-2 和 SP-40 等。在 1992 年英国剑桥召开的国际会议上将其统一命名为 Clusterin，简称 CLU。研究表明 Clusterin 不仅与多种生物过程相关，而且还与多种病理状态（如神经退行性疾病、衰老和癌症）有关。人 Clusterin 包含两个螺旋结构域、三个核定位信号域和一个肝素结合域。细胞内前体的裂解去除信号肽并产生相当大小的α链和β链，分泌为大约80kDa 的 N-糖基化和二硫键连接的异二聚体。

CLU, clusterin 分子靶点种属信息

人 Human

人 Human CLU 分子靶点信息

分子名：CLU, clusterin
别称：
- AAG4
- aging-associated protein 4
- APO-J
- APOJ
- apolipoprotein J
- CLI
- CLU1
- CLU2
- complement cytolysis inhibitor
- complement lysis inhibitor
- complement-associated protein SP-40,40
- kubinding protein 1
- KUB1
- MGC24903
- NA1/NA2
- SGP-2
- SGP2
- SP-40
- sulfated glycoprotein 2
- testosterone-repressed prostate message 2
- TRPM-2
- TRPM2
基因序列：NCBI_Gene: 1191
蛋白序列：UniProtKB: P10909

人 Human CLU靶点分子功能（预测）

Enables several functions, including amyloid-beta binding activity; low-density lipoprotein particle receptor binding activity; and misfolded protein binding activity. Involved in several processes, including positive regulation of cellular component organization; regulation of intrinsic apoptotic signaling pathway; and regulation of protein metabolic process. Located in several cellular components, including apical dendrite; neurofibrillary tangle; and perinuclear endoplasmic reticulum lumen. Part of spherical high-density lipoprotein particle. Colocalizes with cell periphery; cytoskeleton; and membrane. Implicated in artery disease (multiple); breast cancer; diabetic retinopathy; exfoliation syndrome; and muscular disease (multiple). Biomarker of several diseases, including Kawasaki disease; Stevens-Johnson syndrome; autoimmune disease of musculoskeletal system (multiple); eye disease (multiple); and invasive ductal carcinoma.