EK1227

Human BID ELISA Kit 检测试剂盒（酶联免疫吸附法）

¥1,600.00 – ¥2,650.00

分子靶点：BID
种属：人 (Human)
样本类型：血清，血浆，细胞培养上清等
检测样本体积：5 μL
灵敏度：0.51 pg/mL
检测范围：15.63 pg/mL - 1000 pg/mL
回收率：93% - 109%

在售SKU:70-EK1227-48, 70-EK1227-96, EK1227

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库存号

描述

文章目录[隐藏]

分子信息
BID 分子靶点信息概述
BID 分子靶点综述
- 人 Human BID 分子靶点信息
- 人 Human BID靶点分子功能（预测）

商品名	Human BID ELISA Kit 检测试剂盒（酶联免疫吸附法）ELISA试剂盒
检测方法	双抗夹心法
精密度	板内变异系数：2.3% - 3.0%；板间变异系数：1.7% - 2.2%
样本类型	血清、血浆，细胞培养上清等
检测样本体积	5 μL
灵敏度	0.51 pg/mL
检测范围	15.63 pg/mL - 1000 pg/mL
回收率	93% - 109%
平均回收率	1.02
板式	96孔板，可拆
保存	试剂盒未拆开，4℃保存。已拆开，标准品-20℃保存，其它4℃保存。
运输条件	4℃蓝冰运输
组分	包被特异性抗人 BID 抗体的96孔聚苯乙烯酶标板 Human BID冻干标准品 Streptavidin-HRP标记Human BID单克隆检测抗体检测缓冲液(10×) 底物(TMB) 终止液洗液(20×) 封板膜标准品稀释液

检测原理：本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人 BID 抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本和辣根过氧化物酶标记的检测抗体，经过孵育，样本中存在的 BID 与固相抗体和检测抗体结合。洗涤后，加入显色底物 TMB，避光显色。颜色反应的深浅与样本中 BID 的浓度成正比。加入终止液终止反应，在450 nm波长 (参考波长 570 - 630 nm)测定吸光度值。

Human BID ELISA Kit ELISA试剂盒 - 标准曲线 — 标准曲线

分子信息

概述人 Human BID 分子靶点信息

BID 分子靶点信息概述

分子名：BID, BH3 interacting domain death agonist
基因家族：Receptor ligands; BCL2 homology region 3 (BH3) only; MicroRNA protein coding host genes

BID 分子靶点综述

BH3 结构域凋亡诱导蛋白(BID)是 Bcl-2 蛋白家族中的促凋亡成员，只含有 BH3 结构域。BID 对由Bcl-2 家族蛋白酶介导的细胞死亡很重要，是蛋白酶介导的死亡信号的哨兵。在凋亡信号应答中，BID 与另一个 Bcl-2 家族蛋白Bax 相互作用，导致 Bax 插入到细胞器膜上，主要是线粒体外膜。肿瘤抑制基因 p53 可上调 BID 的表达，BID 已被证明可参与p53 介导的细胞凋亡。最近的研究表明，BID 不仅仅是一个杀手分子，它还通过检查有丝分裂来参与维持基因组的稳定性。BID 是内在死亡途径的关键调节者，可增强 caspase 依赖性的和非依赖性的神经元凋亡的实行。因此，药物抑制BID可为治疗神经系统疾病提供一种很有前途的治疗策略，因为神经系统中的程序性细胞死亡很明显。

人 Human BID 分子靶点信息

分子名：BID, BH3 interacting domain death agonist
别称：
- apoptic death agonist
- BH3 interacting domain death agonist Si6 isoform
- BH3-interacting domain death agonist
- BID isoform ES(1b)
- BID isoform L(2)
- BID isoform Si6
- desmocollin type 4
- FP497
- Human BID coding sequence
- MGC15319
- MGC42355
- p22 BID
基因序列：NCBI_Gene: 637
蛋白序列：UniProtKB: P55957

人 Human BID靶点分子功能（预测）

Predicted to enable death receptor binding activity. Involved in several processes, including hepatocyte apoptotic process; positive regulation of apoptotic signaling pathway; and positive regulation of cellular component organization. Located in cytosol and mitochondrial outer membrane. Implicated in pancreatic cancer.