EK1255

Human IGFBP-1 ELISA Kit检测试剂盒（酶联免疫吸附法）

¥1,600.00 – ¥2,650.00

分子靶点：IGFBP1, AFBP, IBP1
种属：人 (Human)
样本类型：血清，血浆，细胞培养上清及其他生物学样本
检测样本体积：10 μL
灵敏度：0.93 pg/mL
检测范围：31.25 pg/mL - 2000 pg/mL
回收率：83% - 118%

在售SKU:70-EK1255-48, 70-EK1255-96

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文章目录[隐藏]

分子信息
IGFBP1 分子靶点信息概述
IGFBP1 分子靶点综述
- 人 Human IGFBP1 分子靶点信息
- 人 Human IGFBP1靶点分子功能（预测）

商品名	Human IGFBP-1 ELISA Kit (人IGFBP-1 ELISA试剂盒)
检测方法	双抗夹心法
精密度	板内变异系数：4.8% - 5.2%；板间变异系数：3.0% - 5.8%
样本类型	血清，血浆，细胞培养上清及其他生物学样本
检测样本体积	10 μL
灵敏度	0.93 pg/mL
检测范围	31.25 pg/mL - 2000 pg/mL
回收率	83% - 118%
平均回收率	1.01
板式	96孔板，可拆
保存	试剂盒未拆开，4℃保存。已拆开，标准品-20℃保存，其它4℃保存。
运输条件	4℃蓝冰运输
组分	包被抗IGFBP-1单克隆抗体的96孔聚苯乙烯酶标板人IGFBP-1冻干标准品 IGFBP-1检测抗体标准品稀释液辣根过氧化物酶标记的链霉亲和素检测缓冲液(10×) 底物(TMB) 终止液洗液(20×) 封板膜

检测原理：本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人IGFBP-1抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品和待测样本，经过孵育，样本中存在的IGFBP-1与固相抗体结合。洗涤去除未结合的物质后，加入生物素化的检测抗体孵育。洗涤去除未结合的生物素化的抗体，加入辣根过氧化物酶标记的链霉亲和素 (Streptavidin-HRP)。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中IGFBP-1的浓度成正比。加入终止液终止反应，在450 nm波长(参考波长570 - 630 nm)测定吸光度值。

Human IGFBP-1 ELISA Kit (人IGFBP-1 ELISA试剂盒) - 标准曲线 — 标准曲线

分子信息

概述人 IGFBP1, AFBP, IBP1 靶点信息

IGFBP1 分子靶点信息概述

分子名：IGFBP1, insulin like growth factor binding protein 1
基因家族：Insulin like growth factor binding proteins
别名：IGF-BP25; AFBP; hIGFBP-1; PP12
曾用名：IBP1
全称：placental protein 12; amniotic fluid binding protein; alpha-pregnancy-associated endometrial globulin; growth hormone independent-binding protein; binding protein-28; binding protein-26; binding protein-25; IGF-binding protein 1; insulin-like growth factor binding protein 1

IGFBP1 分子靶点综述

胰岛素样生长因子-结合蛋白 1(IGFBP-1)也被称为胎盘蛋白 12(PP12)，是一种由 IGFBP1 基因编码的蛋白。它能结合胰岛素样生长因子(IGFs)I 和 II，并在血浆中循环。这样的结合延长了 IGFs 的半衰期，改变了它们与细胞表面受体的相互作用。IGFBPs 可以调节 IGF 蛋白的生物活性。IGFBP 的转录后修饰(如糖基化、磷酸化和蛋白水解)可改变结合蛋白与 IGF 的亲和力。高浓度 IGFBP-1 可能是分解代谢状态的标志，研究表明含高浓度 IGFBP-1 的女性具有较少的肌肉量。鼻咽癌患者血清中较高的 IGFBP-1/IGF-1 比与预后差显著相关。据报道，局部 IGFBP1 水平对冠状动脉斑块的形成有影响。

人 Human IGFBP1 分子靶点信息

分子名：IGFBP1, insulin like growth factor binding protein 1
别称：
- AFBP
- alpha-pregnancy-associated endometrial globulin
- amniotic fluid binding protein
- binding protein-25
- binding protein-26
- binding protein-28
- growth hormone independent-binding protein
- hIGFBP-1
- IBP-1
- IBP1
- IGF-binding protein 1
- IGF-BP25
- IGFBP-1
- insulin-like growth factor binding protein 1
- insulin-like growth factor-binding protein 1
- placental protein 12
- PP12
基因序列：NCBI_Gene: 3484
蛋白序列：UniProtKB: P08833

人 Human IGFBP1靶点分子功能（预测）

Enables insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Predicted to be involved in regulation of insulin-like growth factor receptor signaling pathway. Located in Golgi apparatus. Implicated in diabetic angiopathy. Biomarker of breast cancer.