EK101A

Human IL-1a ELISA Kit检测试剂盒（酶联免疫吸附法）

¥1,600.00 – ¥2,650.00

分子靶点：IL1A, IL1-α, IL1F1
种属：人 (Human)
样本类型：血清，血浆，细胞培养上清及其他生物学样本
检测样本体积：50 μL 1×检测缓冲液和50 μL样本
灵敏度：0.52 pg/mL
检测范围：7.81 pg/mL - 500 pg/mL
回收率：81% - 106%

在售SKU:70-EK101A-48, 70-EK101A-96, 人白介素1α, 白介素1α, 白介素1A, 人, 白介素, 1, α, alpha

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库存号

描述

文章目录[隐藏]

分子信息
IL1A 分子靶点信息概述
IL1A 分子靶点综述
- 人 Human IL1A 分子靶点信息
- 人 Human IL1A靶点分子功能（预测）

商品名	Human IL-1α ELISA Kit (人白介素1α ELISA试剂盒)
检测方法	双抗夹心法
精密度	板内变异系数：2.5% - 4.4%；板间变异系数：3.9% - 6.8%
样本类型	血清，血浆，细胞培养上清及其他生物学样本
检测样本体积	50 μL 1×检测缓冲液和50 μL样本
灵敏度	0.52 pg/mL
检测范围	7.81 pg/mL - 500 pg/mL
回收率	81% - 106%
平均回收率	0.93
板式	96孔板，可拆
保存	试剂盒未拆开，4℃保存。已拆开，标准品-20℃保存，其它4℃保存。
运输条件	4℃蓝冰运输
组分	包被抗IL-1α单克隆抗体的96孔聚苯乙烯酶标板人IL-1α冻干标准品 IL-1α检测抗体标准品稀释液检测缓冲液(10×) 底物(TMB) 终止液洗液(20×) 封板膜

检测原理：本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人IL-1α抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本和生物素化的检测抗体，经过孵育，样本中存在的IL-1α与固相抗体和检测抗体结合。洗涤去除未结合的物质后，加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中IL-1α的浓度成正比。加入终止液终止反应，在450 nm波长(参考波长570 - 630 nm)测定吸光度值。

Human IL-1α ELISA Kit (人白介素1α ELISA试剂盒) - 标准曲线 — 标准曲线

分子信息

概述人 IL1A, IL1-α, IL1F1 靶点信息

IL1A 分子靶点信息概述

分子名：IL1A, interleukin 1 alpha
基因家族：Interleukins
别名：IL1F1; IL-1A; IL1-ALPHA
曾用名：IL1
全称：preinterleukin 1 alpha; hematopoietin-1; pro-interleukin-1-alpha

IL1A 分子靶点综述

白细胞介素1(IL-1)是17kDa的胞外多肽，分为IL-1α和IL-1β两种蛋白。IL-1α是一种多效性细胞因子，在人类中由IL1A基因编码。IL-1α主要由活化的巨噬细胞、中性粒细胞、上皮细胞和内皮细胞产生。它具有代谢、生理、造血活性，在调节免疫应答中起到核心作用。IL-1α可与HAX1、NDN相互作用，但是与TNF之间的协同作用是临床上最相关的。IL-1α和TNF都是急性期细胞因子，具有促发热和发炎作用。人们目前正在评估IL-1α是否可作为临床试验中一个潜在治疗肿瘤的标志物。阻断IL-1α活性具有潜在治疗皮肤病的作用，例如痤疮。

人 Human IL1A 分子靶点信息

分子名：IL1A, interleukin 1 alpha
别称：
- hematopoietin-1
- IL-1 alpha
- IL-1A
- IL1
- IL1-ALPHA
- IL1F1
- interleukin 1, alpha
- interleukin-1 alpha
- preinterleukin 1 alpha
- pro-interleukin-1-alpha
基因序列：NCBI_Gene: 3552
蛋白序列：UniProtKB: P01583

人 Human IL1A靶点分子功能（预测）

Enables copper ion binding activity and cytokine activity. Involved in several processes, including positive regulation of interleukin-2 production; positive regulation of mitotic nuclear division; and response to copper ion. Located in cytosol and extracellular space. Implicated in several diseases, including Fabry disease; Schnitzler syndrome; autoimmune disease (multiple); hematologic cancer (multiple); and lung disease (multiple). Biomarker of several diseases, including autoimmune disease (multiple); cholesteatoma (multiple); common cold; cystic fibrosis; and osteoarthritis.