IGFBP1 靶点信息

IGFBP1 分子靶点信息概述

  • 分子名：IGFBP1, insulin like growth factor binding protein 1
  • 基因家族：Insulin like growth factor binding proteins
  • 别名：IGF-BP25; AFBP; hIGFBP-1; PP12
  • 曾用名：IBP1
  • 全称：placental protein 12; amniotic fluid binding protein; alpha-pregnancy-associated endometrial globulin; growth hormone independent-binding protein; binding protein-28; binding protein-26; binding protein-25; IGF-binding protein 1; insulin-like growth factor binding protein 1

IGFBP1 分子靶点综述

胰岛素样生长因子-结合蛋白 1(IGFBP-1)也被称为胎盘蛋白 12(PP12)，是一种由 IGFBP1 基因 编码的蛋白。它能结合胰岛素样生长因子(IGFs)I 和 II，并在血浆中循环。这样的结合延长了 IGFs 的半衰期，改变了它们与细胞表面受体的相互作用。IGFBPs 可以调节 IGF 蛋白的生物活性。IGFBP 的转录后修饰(如糖基化、磷酸化和蛋白水解)可改变结合蛋白与 IGF 的亲和力。高浓度 IGFBP-1 可能是分解代谢状态的标志，研究表明含高浓度 IGFBP-1 的女性具有较少的肌肉量。鼻咽癌患者 血清中较高的 IGFBP-1/IGF-1 比与预后差显著相关。据报道，局部 IGFBP1 水平对冠状动脉斑块的 形成有影响。

IGFBP1, insulin like growth factor binding protein 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IGFBP1 分子靶点信息

  • 分子名：IGFBP1, insulin like growth factor binding protein 1
  • 别称：
    • AFBP
    • alpha-pregnancy-associated endometrial globulin
    • amniotic fluid binding protein
    • binding protein-25
    • binding protein-26
    • binding protein-28
    • growth hormone independent-binding protein
    • hIGFBP-1
    • IBP-1
    • IBP1
    • IGF-binding protein 1
    • IGF-BP25
    • IGFBP-1
    • insulin-like growth factor binding protein 1
    • insulin-like growth factor-binding protein 1
    • placental protein 12
    • PP12
  • 基因序列：NCBI_Gene: 3484
  • 蛋白序列：UniProtKB: P08833

人 Human IGFBP1靶点分子功能（预测）

Enables insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Predicted to be involved in regulation of insulin-like growth factor receptor signaling pathway. Located in Golgi apparatus. Implicated in diabetic angiopathy. Biomarker of breast cancer.

小鼠 Mouse Igfbp1 分子靶点信息

小鼠 Mouse Igfbp1 靶点分子功能（预测）

Enables insulin-like growth factor binding activity. Predicted to be involved in regulation of insulin-like growth factor receptor signaling pathway. Located in extracellular space. Is expressed in several structures, including blastocyst; early embryo; liver; and secondary oocyte. Human ortholog(s) of this gene implicated in diabetic angiopathy. Orthologous to human IGFBP1 (insulin like growth factor binding protein 1).

大鼠 Rat Igfbp1 分子靶点信息

  • 分子名：Igfbp1, insulin-like growth factor binding protein 1
  • 别称：
    • IBP-1
    • IBP1
    • IGF-binding protein 1
    • IGF-BP25
    • IGFBA
    • IGFBP-1
    • insulin-like growth factor-binding protein 1
    • placental protein 12
  • 基因序列：NCBI_Gene: 25685
  • 蛋白序列：UniProtKB: P21743

大鼠 Rat Igfbp1 靶点分子功能（预测）

Predicted to enable insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Involved in several processes, including insulin receptor signaling pathway; positive regulation of cell growth; and tissue regeneration. Located in extracellular space. Human ortholog(s) of this gene implicated in diabetic angiopathy. Orthologous to human IGFBP1 (insulin like growth factor binding protein 1).

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