EK1296

Human IGFBP-6 ELISA Kit检测试剂盒（酶联免疫吸附法）

¥1,600.00 – ¥2,650.00

分子靶点：IGFBP6
种属：人 (Human)
样本类型：血清，血浆，细胞培养上清及其他生物学样本
检测样本体积：20 μL
灵敏度：8.38 pg/mL
检测范围：62.5 pg/mL - 4000 pg/mL
回收率：87% - 103%

在售SKU:70-EK1296-48, 70-EK1296-96

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文章目录[隐藏]

分子信息
IGFBP6 分子靶点信息概述
IGFBP6 分子靶点综述
- 人 Human IGFBP6 分子靶点信息
- 人 Human IGFBP6靶点分子功能（预测）

商品名	Human IGFBP-6 ELISA Kit (人 IGFBP-6 ELISA试剂盒)
检测方法	双抗夹心法
精密度	板内变异系数：0.8% - 1.2%；板间变异系数：0.8% - 2.0%
样本类型	血清，血浆，细胞培养上清及其他生物学样本
检测样本体积	20 μL
灵敏度	8.38 pg/mL
检测范围	62.5 pg/mL - 4000 pg/mL
回收率	87% - 103%
平均回收率	0.96
板式	96孔板，可拆
保存	试剂盒未拆开，4℃保存。已拆开，标准品-20℃保存，其它4℃保存。
运输条件	4℃蓝冰运输
组分	包被抗IGFBP-6单克隆抗体的96孔聚苯乙烯酶标板人IGFBP-6冻干标准品 IGFBP-6检测抗体标准品稀释液检测缓冲液(10×) 底物(TMB) 终止液洗液(20×) 封板膜

检测原理：本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人IGFBP-6抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本和生物素化的检测抗体，经过孵育，样本中存在的IGFBP-6与固相抗体和检测抗体结合。洗涤去除未结合的物质后，加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中IGFBP-6的浓度成正比。加入终止液终止反应，在450 nm波长(参考波长570 - 630 nm)测定吸光度值。

Human IGFBP-6 ELISA Kit (人 IGFBP-6 ELISA试剂盒) - 标准曲线 — 标准曲线

分子信息

概述人 IGFBP6 靶点信息

IGFBP6 分子靶点信息概述

分子名：IGFBP6, insulin like growth factor binding protein 6
基因家族：Insulin like growth factor binding proteins
全称：insulin-like growth factor binding protein 6

IGFBP6 分子靶点综述

胰岛素样生长因子(IGF)结合蛋白超家族包括六种高亲和力IGF结合蛋白(IGFBP)和至少四种被称为IGFBP相关蛋白(IGFBP-rP)的低亲和力结合蛋白。所有IGFBP超家族成员都是富含半胱氨酸的蛋白质，具有保守的半胱氨酸残基。IGFBPs有助于延长所有组织(包括前列腺)中IGF的半衰期。在人类中，胰岛素样生长因子结合蛋白6(IGFBP-6)是一个由IGFBP6基因编码的蛋白质。IGFBP-6结合IGF-II比IGF-I具有更高的亲和力，且它是IGF-II特异性的抑制剂。据报道，IGFBP-6不依赖于IGF，在细胞增殖、存活、分化和迁移中发挥作用。IGFBP-6由于其明显的IGF-II结合偏好，在IGFBPs中是独一无二的。

人 Human IGFBP6 分子靶点信息

分子名：IGFBP6, insulin like growth factor binding protein 6
别称：
- IBP-6
- IBP6
- IGF binding protein 6
- IGF-binding protein 6
- IGFBP-6
- insulin-like growth factor binding protein 6
- insulin-like growth factor-binding protein 6
基因序列：NCBI_Gene: 3489
蛋白序列：UniProtKB: P24592

人 Human IGFBP6靶点分子功能（预测）

Enables identical protein binding activity and insulin-like growth factor II binding activity. Involved in cell migration and positive regulation of stress-activated MAPK cascade. Part of insulin-like growth factor binary complex. Implicated in obesity. Biomarker of breast cancer; in situ carcinoma; leiomyoma; and neovascular inflammatory vitreoretinopathy.