EK1119

Human CXCL12/SDF-1 ELISA Kit检测试剂盒（酶联免疫吸附法）

¥1,600.00 – ¥2,650.00

分子靶点：CXCL12, SDF1, PBSF
种属：人 (Human)
样本类型：血清，血浆，细胞培养上清及其他生物学样本
检测样本体积：20 μL
灵敏度：18.13 pg/mL
检测范围：62.5 pg/mL - 4000 pg/mL
回收率：89% - 110%

在售SKU:70-EK1119-48, 70-EK1119-96

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文章目录[隐藏]

分子信息
CXCL12 分子靶点信息概述
CXCL12 分子靶点综述
- 人 Human CXCL12 分子靶点信息
- 人 Human CXCL12靶点分子功能（预测）

商品名	Human CXCL12/SDF-1 ELISA Kit (人趋化因子CXC配体12 ELISA试剂盒)
检测方法	双抗夹心法
精密度	板内变异系数：2.4% - 2.6%；板间变异系数：3.0% - 4.5%
样本类型	血清，血浆，细胞培养上清及其他生物学样本
检测样本体积	20 μL
灵敏度	18.13 pg/mL
检测范围	62.5 pg/mL - 4000 pg/mL
回收率	89% - 110%
平均回收率	1.02
板式	96孔板，可拆
保存	试剂盒未拆开，4℃保存。已拆开，标准品-20℃保存，其它4℃保存。
运输条件	4℃蓝冰运输
组分	包被抗CXCL12/SDF-1单克隆抗体的96孔聚苯乙烯酶标板人CXCL12/SDF-1冻干标准品 CXCL12/SDF-1检测抗体标准品稀释液检测缓冲液(10×) 底物(TMB) 终止液洗液(20×) 封板膜

检测原理：本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人CXCL12抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本和生物素化的检测抗体，经过孵育，样本中存在的CXCL12与固相抗体和检测抗体结合。洗涤去除未结合的物质后，加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中CXCL12的浓度成正比。加入终止液终止反应，在450 nm波长(参考波长570 - 630 nm)测定吸光度值。

Human CXCL12/SDF-1 ELISA Kit (人趋化因子CXC配体12 ELISA试剂盒) - 标准曲线 — 标准曲线

分子信息

概述人 CXCL12, SDF1, PBSF 靶点信息

CXCL12 分子靶点信息概述

分子名：CXCL12, C-X-C motif chemokine ligand 12
基因家族：Chemokine ligands
别名：SCYB12; SDF-1a; SDF-1b; PBSF; TLSF-a; TLSF-b; TPAR1
曾用名：SDF1A; SDF1B; SDF1
全称：stromal cell-derived factor 1; chemokine (C-X-C motif) ligand 12

CXCL12 分子靶点综述

趋化因子CXC配体12(CXCL12)也称为基质细胞衍生因子1(SDF-1)，是一种可活化白细胞的趋化因子蛋白，通常由促炎性刺激剂诱导产生，如LPS、TNF或IL-1。CXCL12对淋巴细胞具有强烈的趋化作用。在胚胎发生期，它可促使造血细胞从胎肝向骨髓迁移和大血管的形成。在成年人中，CXCL12在血管生成中具有重要作用，它通过CXCR4依赖的机制招募骨髓中的内皮祖细胞(EPCs)。CXCL12对肿瘤转移也有作用，表达CXCR4受体的癌细胞可被吸引至靶组织。然而在乳腺癌中，CXCL12表达升高则提示远端转移的风险降低。

人 Human CXCL12 分子靶点信息

分子名：CXCL12, C-X-C motif chemokine ligand 12
别称：
- chemokine (C-X-C motif) ligand 12
- intercrine reduced in hepatomas
- IRH
- PBSF
- pre-B cell growth-stimulating factor
- SCYB12
- SDF-1a
- SDF-1b
- SDF1
- SDF1A
- SDF1B
- stromal cell-derived factor 1
- TLSF
- TLSF-a
- TLSF-b
- TPAR1
基因序列：NCBI_Gene: 6387
蛋白序列：UniProtKB: P48061

人 Human CXCL12靶点分子功能（预测）

Enables CXCR chemokine receptor binding activity; chemokine activity; and integrin binding activity. Involved in several processes, including integrin activation; negative regulation of apoptotic process; and regulation of leukocyte migration. Acts upstream of or within positive regulation of T cell migration and positive regulation of cell adhesion. Located in extracellular exosome. Part of collagen-containing extracellular matrix. Implicated in breast carcinoma; diabetic angiopathy; human immunodeficiency virus infectious disease; and type 1 diabetes mellitus. Biomarker of diabetic retinopathy; insulinoma; periodontitis; and type 2 diabetes mellitus.