F11011C01

Anti-Human CD11c, FITC (Clone:3.9)检测试剂

¥600.00 – ¥1,320.00

说明书

分子靶点：CD11C, ITGAX
种属：人 (Human)
标记：FITC
亚型：Mouse IgG1, κ
克隆号：3.9

在售SKU, 70-AH011C01-20, 70-AH011C01-50, 70-AH011C01-100, AH011C01, 70-F11011C01-25, 70-F11011C01-100

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Size
库存号

描述

文章目录[隐藏]

结果示例
分子信息
ITGAX 分子靶点信息概述
ITGAX 分子靶点综述
- 人 Human ITGAX 分子靶点信息
- 人 Human ITGAX靶点分子功能（预测）

商品名	Anti-Human CD11c, FITC (Clone:3.9)检测试剂
靶点	CD11C, ITGAX
标记	FITC
仪器	适用488nm激光器的流式细胞仪
亚型	Mouse IgG1, κ
克隆号	3.9
推荐应用	流式检测
用量	5 μL /Test
纯化	亲和层析
储存液	含 0.2% BSA 和 0.2% proclin 950 的磷酸盐缓冲液(pH7.2)
保存条件	2 - 8℃避光，切勿冻存

结果示例

图 - 人外周血染色 Anti-Human CD11c, FITC (F11011C01) 和 Anti-Human CD14, APC (F1101403) 的结果。以 FSC/SSC 中的淋巴细胞和单核细胞设门进行分析。

分子信息

概述人 CD11C, ITGAX 靶点信息

ITGAX 分子靶点信息概述

分子名：ITGAX, integrin subunit alpha X
基因家族：CD molecules; Integrin alpha subunits; Complement system regulators and receptors
别名：CD11c
曾用名：CD11C
全称：complement component 3 receptor 4 subunit; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); integrin, alpha X (complement component 3 receptor 4 subunit)

ITGAX 分子靶点综述

CD11c被称为补体受体4 (Complement receptor, CR4)，是黏附分子CD11/CD18家族中的一员，属于I型跨膜糖蛋白，高表达于髓系DCs表面。CD11c作为一正性调控因子，参与DCs的黏附、迁移，抗原的识别和呈递，并激活CD4+、CD8+ T细胞，调控免疫应答发生，在感染和抗肿瘤免疫中发挥重要作用。

人 Human ITGAX 分子靶点信息

分子名：ITGAX, integrin subunit alpha X
别称：
- CD11 antigen-like family member C
- CD11C
- complement component 3 receptor 4 subunit
- integrin alpha X
- integrin alpha-X
- integrin, alpha X (antigen CD11C (p150), alpha polypeptide)
- integrin, alpha X (complement component 3 receptor 4 subunit)
- leu M5, alpha subunit
- leukocyte adhesion glycoprotein p150,95 alpha chain
- leukocyte adhesion receptor p150,95
- leukocyte surface antigen p150,95, alpha subunit
- myeloid membrane antigen, alpha subunit
- p150 95 integrin alpha chain
- SLEB6
基因序列：NCBI_Gene: 3687
蛋白序列：UniProtKB: P20702

人 Human ITGAX靶点分子功能（预测）

Enables receptor tyrosine kinase binding activity. Involved in several processes, including heterotypic cell-cell adhesion; positive regulation of angiogenesis; and positive regulation of endothelial tube morphogenesis. Located in cell surface.

操作步骤

文章目录[隐藏]

使用方法
注意事项
FCM流式检测常见问题
查看更多FCM流式检测相关问题

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使用方法

全血样本：取 50 - 100 μl 抗凝血，加入 5 μl Anti-Human CD11c, FITC 和其他抗体，震荡混匀，于室温避光孵育 15 分钟或 2 - 8℃避光孵育 30 分钟。根据红细胞裂解液说明书进行操作，去除红细胞。300 × g 离心 5 - 10 分钟，弃上清，加入 500 μl 流式染色缓冲液重悬，上机检测。
其他样本：将 1×10⁵ - 10⁸ 个单细胞经适当离心后，取适量流式染色缓冲液 (目录号 S1001)重悬，加入 5 μl Anti-Human CD11c, FITC 和其他抗体，使反应终体积为 100 μl。震荡混匀，于室温避光孵育15 分钟或 2 - 8℃避光孵育 30 分钟。每管加入 1 - 2 ml 流式染色缓冲液，300 × g 离心 5 - 10 分钟，弃上清，加入 500 μl 流式染色缓冲液重悬，上机检测。
实验中，可对抗体进行优化滴定以获得最佳效果。