F1110503

Anti-Human CD105, APC (Clone: 00244) 检测试剂

¥1,544.00 – ¥3,264.00

说明书

分子靶点：RNG, endoglin, CD105
种属：人 (Human)
标记：APC
亚型：Mouse IgG1, κ
克隆号：00244

在售SKU, F1110503, 70-F1110503-25, 70-F1110503-100

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Size
库存号

描述

文章目录[隐藏]

结果示例
分子信息
ENG 分子靶点信息概述
ENG 分子靶点综述
- 人 Human ENG 分子靶点信息
- 人 Human ENG靶点分子功能（预测）

商品名	Anti-Human CD105, APC (Clone: 00244) 检测试剂
靶点	RNG, endoglin, CD105
标记	APC
仪器	适用633nm激光器的流式细胞仪
亚型	Mouse IgG1, κ
克隆号	00244
推荐应用	流式检测
用量	5 μL/Test
纯化	亲和层析
储存液	含 0.2% BSA 和 0.2% proclin 950 的磷酸盐缓冲液(pH7.2)
保存条件	2 - 8℃避光，切勿冻存

结果示例

图 - 人白血病细胞(TF-1)染色，Mouse IgG1, κ Isotype control, APC和Anti-Human CD105, APC的染色结果。

分子信息

概述人 RNG, endoglin, CD105 靶点信息

ENG 分子靶点信息概述

分子名：ENG, endoglin
基因家族：CD molecules
别名：END; HHT1; CD105
曾用名：ORW1; ORW
全称：Osler-Rendu-Weber syndrome 1

ENG 分子靶点综述

内皮糖蛋白(Endoglin)，又称为CD105，是位于细胞膜表面的I型跨膜糖蛋白，是TGF-β受体复合物之一。它参与调控与TGF-β1、TGF-β3、Activin-A、BMP-2和BMP-7结合的应答。Endoglin被推测参与影响细胞形态和迁移的细胞骨架构成。它在心血管系统发育和血管重塑中发挥作用。在心脏发育过程中，Endoglin的表达受到调控。缺失Endoglin基因的实验小鼠由于心血管异常而死亡。在人类中，Endoglin可能参与常染色体显性疾病，为人熟知的是1型遗传性出血性毛细血管扩张症(HHT)。它会导致频繁的鼻出血、皮肤和粘膜毛细管扩张，在不同的器官(如大脑、肺和肝脏)中引起动静脉畸形。

人 Human ENG 分子靶点信息

分子名：ENG, endoglin
别称：
- CD105
- CD105 antigen
- END
- FLJ41744
- HHT1
- ORW
- ORW1
基因序列：NCBI_Gene: 2022
蛋白序列：UniProtKB: P17813

人 Human ENG靶点分子功能（预测）

Enables several functions, including galactose binding activity; protein homodimerization activity; and transforming growth factor beta receptor binding activity. Contributes to BMP binding activity and transforming growth factor beta binding activity. Involved in several processes, including central nervous system vasculogenesis; regulation of transcription by RNA polymerase II; and regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Located in external side of plasma membrane; extracellular space; and nuclear body. Part of receptor complex. Implicated in arteriovenous malformation; arteriovenous malformations of the brain; breast cancer; hereditary hemorrhagic telangiectasia; and intracranial aneurysm. Biomarker of several diseases, including artery disease (multiple); clear cell renal cell carcinoma; diabetic retinopathy; hematologic cancer (multiple); and secondary hyperparathyroidism.

操作步骤

文章目录[隐藏]

使用方法
注意事项
FCM流式检测常见问题
查看更多FCM流式检测相关问题

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使用方法

全血样本：取100 μl 抗凝血，加入5 μl Anti-Human CD105, APC 和其他抗体，震荡混匀，于室温避光孵育15 分钟或2 - 8℃避光孵育30 分钟。根据红细胞裂解液说明书进行操作，去除红细胞。300×g 离心 5 - 10 分钟，弃上清，加入 500 μl 流式染色缓冲液重悬，上机检测。
其他样本：将 1×10⁵ - 10⁸ 个单细胞经适当离心后，取适量流式染色缓冲液 (目录号S1001)重悬，加入5 μl Anti-Human CD105, APC 和其他抗体，使反应终体积为 100 μl。震荡混匀，于室温避光孵育15 分钟或 2 - 8℃避光孵育 30 分钟。每管加入 1 - 2 ml 流式染色缓冲液，300 × g 离心 5 - 10 分钟，弃上清，加入 500 μl 流式染色缓冲液重悬，上机检测。