F1110503

Anti-Human CD105, APC (Clone: 00244) 检测试剂

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¥1,544.00¥3,264.00

  • 分子靶点:RNG, endoglin, CD105
  • 种属:人 (Human)
  • 标记:APC
  • 亚型:Mouse IgG1, κ
  • 克隆号:00244

在售SKU, F1110503, 70-F1110503-25, 70-F1110503-100

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描述

商品名

Anti-Human CD105, APC (Clone: 00244) 检测试剂

靶点

RNG, endoglin, CD105

标记

APC

仪器

适用633nm激光器的流式细胞仪

亚型

Mouse IgG1, κ

克隆号

00244

推荐应用

流式检测

用量

5 μL/Test

纯化

亲和层析

储存液

含 0.2% BSA 和 0.2% proclin 950 的磷酸盐缓冲液(pH7.2)

保存条件

2 - 8℃避光,切勿冻存

结果示例

Anti-Human CD105, APC (Clone: 00244)  - 结果示例图片
结果示例

图 - 人白血病细胞(TF-1)染色,Mouse IgG1, κ Isotype control, APC和Anti-Human CD105, APC的染色结果。

分子信息

概述人 RNG, endoglin, CD105 靶点信息

ENG 分子靶点信息概述

  • 分子名:ENG, endoglin
  • 基因家族:CD molecules
  • 别名:END; HHT1; CD105
  • 曾用名:ORW1; ORW
  • 全称:Osler-Rendu-Weber syndrome 1

ENG 分子靶点综述

内皮糖蛋白(Endoglin),又称为CD105,是位于细胞膜表面的I型跨膜糖蛋白,是TGF-β受体复合物之一。它参与调控与TGF-β1、TGF-β3、Activin-A、BMP-2和BMP-7结合的应答。Endoglin被推测参与影响细胞形态和迁移的细胞骨架构成。它在心血管系统发育和血管重塑中发挥作用。在心脏发育过程中,Endoglin的表达受到调控。缺失Endoglin基因的实验小鼠由于心血管异常而死亡。在人类中,Endoglin可能参与常染色体显性疾病,为人熟知的是1型遗传性出血性毛细血管扩张症(HHT)。它会导致频繁的鼻出血、皮肤和粘膜毛细管扩张,在不同的器官(如大脑、肺和肝脏)中引起动静脉畸形。

人 Human ENG 分子靶点信息

人 Human ENG靶点分子功能(预测)

Enables several functions, including galactose binding activity; protein homodimerization activity; and transforming growth factor beta receptor binding activity. Contributes to BMP binding activity and transforming growth factor beta binding activity. Involved in several processes, including central nervous system vasculogenesis; regulation of transcription by RNA polymerase II; and regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Located in external side of plasma membrane; extracellular space; and nuclear body. Part of receptor complex. Implicated in arteriovenous malformation; arteriovenous malformations of the brain; breast cancer; hereditary hemorrhagic telangiectasia; and intracranial aneurysm. Biomarker of several diseases, including artery disease (multiple); clear cell renal cell carcinoma; diabetic retinopathy; hematologic cancer (multiple); and secondary hyperparathyroidism.

操作步骤


下载本产品说明书

使用方法

全血样本:取100 μl 抗凝血,加入5 μl Anti-Human CD105, APC 和其他抗体,震荡混匀,于室温避光孵育15 分钟或2 - 8℃避光孵育30 分钟。根据红细胞裂解液说明书进行操作,去除红细胞。300×g 离心 5 - 10 分钟,弃上清,加入 500 μl 流式染色缓冲液重悬,上机检测。
其他样本:将 1×105 - 108 个单细胞经适当离心后,取适量流式染色缓冲液 (目录号S1001)重悬,加入5 μl Anti-Human CD105, APC 和其他抗体,使反应终体积为 100 μl。震荡混匀,于室温避光孵育15 分钟或 2 - 8℃避光孵育 30 分钟。每管加入 1 - 2 ml 流式染色缓冲液,300 × g 离心 5 - 10 分钟,弃上清,加入 500 μl 流式染色缓冲液重悬,上机检测。

注意事项

  1. 请在使用本产品前仔细阅读说明书。本产品仅用于科研,不可用于诊断。
  2. 为了您的安全和健康,请穿戴实验防护服、手套、口罩等必要的防护装备。
  3. 更多相关产品敬请关注联科生物网站或来电咨询。

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