EK317HS

Rat IL-17A High Sensitivity ELISA Kit检测试剂盒（酶联免疫吸附法）

¥2,000.00 – ¥3,400.00

分子靶点：IL17A, IL17, CTLA8
种属：大鼠 (Rat)
样本类型：血清，血浆，细胞培养上清及其他生物学样本
检测样本体积：20 μL
灵敏度：0.15 pg/mL
检测范围：1.56 pg/mL - 100 pg/mL
回收率：94% - 117%

在售SKU:70-EK317HS-48, 70-EK317HS-96

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描述

文章目录[隐藏]

分子信息
IL17A 分子靶点信息概述
IL17A 分子靶点综述
- 大鼠 Rat Il17a 分子靶点信息
- 大鼠 Rat Il17a 靶点分子功能（预测）

商品名	Rat IL-17A High Sensitivity ELISA Kit (大鼠白细胞介素17A高敏 ELISA试剂盒)
检测方法	双抗夹心法
精密度	板内变异系数：2.5% - 4.5%；板间变异系数：2.9% - 4.5%
样本类型	血清，血浆，细胞培养上清及其他生物学样本
检测样本体积	20 μL
灵敏度	0.15 pg/mL
检测范围	1.56 pg/mL - 100 pg/mL
回收率	94% - 117%
平均回收率	1.02
板式	96孔板，可拆
保存	试剂盒未拆开，4℃保存。已拆开，标准品-20℃保存，其它4℃保存。
运输条件	4℃蓝冰运输
组分	包被抗IL-17AA单克隆抗体的96孔聚苯乙烯酶标板大鼠IL-17AA冻干标准品 IL-17AA检测抗体标准品稀释液检测缓冲液(10×) 底物(TMB) 终止液洗液(20×) 封板膜

检测原理：本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗大鼠IL-17A抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品和待测样本，经过孵育，样本中存在的IL-17A与固相抗体结合。洗涤去除未结合的物质后，加入生物素化的检测抗体孵育。洗涤去除未结合的生物素化的抗体，加入辣根过氧化物酶标记的链霉亲和素 (Streptavidin-HRP)。洗涤后，加入信号增强剂孵育，洗涤去除未结合的物质后，再次加入Streptavidin-HRP。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中IL-17A的浓度成正比。加入终止液终止反应，在450 nm波长(参考波长570 - 630 nm)测定吸光度值。

Rat IL-17A High Sensitivity ELISA Kit (大鼠白细胞介素17A高敏 ELISA试剂盒) - 标准曲线 — 标准曲线

分子信息

概述大鼠 IL17A, IL17, CTLA8 靶点信息

IL17A 分子靶点信息概述

分子名：IL17A, interleukin 17A
基因家族：Interleukins
别名：IL-17A; IL-17
曾用名：CTLA8; IL17
全称：cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)

IL17A 分子靶点综述

IL-17主要由Th17型细胞产生，是目前已发现的30余种白细胞介素中的一员，按序号排在第17位。该家族包括6个成员配体(IL-17A ~ IL-17F)和5个受体(IL-17RA ~ IL-17RD和SEF)。IL-17是一种主要由活化的T细胞产生的致炎细胞因子，可以促进T细胞的激活和刺激上皮细胞、内皮细胞、成纤维细胞产生多种细胞因子，从而导致炎症的产生。

大鼠 Rat Il17a 分子靶点信息

分子名：Il17a, interleukin 17A
别称：
- CTLA-8
- cytotoxic T-lymphocyte-associated antigen 8
- hypothetical protein LOC301289
- IL-17
- IL-17A
- Il17
- interleukin 17
- Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
- interleukin-17A
- LOC301289
- similar to Interleukin-17 precursor (IL-17) (Cytotoxic T lymphocyte-associated antigen 8) (CTLA-8)
基因序列：NCBI_Gene: 301289
蛋白序列：
- UniprotKB: G3V7M4
- UniprotKB: Q61453

大鼠 Rat Il17a 靶点分子功能（预测）

Predicted to enable protein heterodimerization activity and protein homodimerization activity. Involved in several processes, including cellular response to glucocorticoid stimulus; positive regulation of necrotic cell death; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and extracellular space. Used to study anti-basement membrane glomerulonephritis; congestive heart failure; myocarditis; pleurisy; and uveitis. Biomarker of several diseases, including acute necrotizing pancreatitis; inflammatory bowel disease (multiple); lipoid nephrosis; lung disease (multiple); and periodontal disease (multiple). Human ortholog(s) of this gene implicated in Mycobacterium avium complex disease; autoimmune disease (multiple); bronchial disease (multiple); macular degeneration; and rhinitis (multiple). Orthologous to human IL17A (interleukin 17A).