IL17A 靶点信息

IL17A 分子靶点信息概述

  • 分子名：IL17A, interleukin 17A
  • 基因家族：Interleukins
  • 别名：IL-17A; IL-17
  • 曾用名：CTLA8; IL17
  • 全称：cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)

IL17A 分子靶点综述

IL-17主要由Th17型细胞产生，是目前已发现的30余种白细胞介素中的一员，按序号排在第17位。该家族包括6个成员配体(IL-17A ~ IL-17F)和5个受体(IL-17RA ~ IL-17RD和SEF)。IL-17是一种主要由活化的T细胞产生的致炎细胞因子，可以促进T细胞的激活和刺激上皮细胞、内皮细胞、成纤维细胞产生多种细胞因子，从而导致炎症的产生。

IL17A, interleukin 17A 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IL17A 分子靶点信息

  • 分子名：IL17A, interleukin 17A
  • 别称：
    • CTLA-8
    • CTLA8
    • cytotoxic T-lymphocyte-associated antigen 8
    • cytotoxic T-lymphocyte-associated protein 8
    • cytotoxic T-lymphocyte-associated serine esterase 8
    • IL-17
    • IL-17A
    • IL17
    • ILA17
    • interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
    • interleukin-17
    • interleukin-17A
  • 基因序列：NCBI_Gene: 3605
  • 蛋白序列：UniProtKB: Q16552

人 Human IL17A靶点分子功能（预测）

Predicted to enable cytokine activity; protein heterodimerization activity; and protein homodimerization activity. Involved in several processes, including interleukin-17-mediated signaling pathway; positive regulation of cytokine production; and positive regulation of osteoclast differentiation. Acts upstream of or within positive regulation of cytokine production and positive regulation of transcription by RNA polymerase II. Predicted to be located in extracellular region. Implicated in Mycobacterium avium complex disease; autoimmune disease (multiple); bronchial disease (multiple); macular degeneration; and rhinitis (multiple). Biomarker of several diseases, including acne; autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and rhinitis (multiple).

小鼠 Mouse Il17a 分子靶点信息

小鼠 Mouse Il17a 靶点分子功能（预测）

Enables protein heterodimerization activity and protein homodimerization activity. Involved in several processes, including defense response to other organism; intestinal epithelial structure maintenance; and positive regulation of gene expression. Acts upstream of or within cellular response to interleukin-1; positive regulation of cytokine production involved in inflammatory response; and positive regulation of transcription by RNA polymerase II. Located in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in Mycobacterium avium complex disease; autoimmune disease (multiple); bronchial disease (multiple); eye disease (multiple); and rhinitis (multiple). Orthologous to human IL17A (interleukin 17A).

大鼠 Rat Il17a 分子靶点信息

  • 分子名：Il17a, interleukin 17A
  • 别称：
    • CTLA-8
    • cytotoxic T-lymphocyte-associated antigen 8
    • hypothetical protein LOC301289
    • IL-17
    • IL-17A
    • Il17
    • interleukin 17
    • Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
    • interleukin-17A
    • LOC301289
    • similar to Interleukin-17 precursor (IL-17) (Cytotoxic T lymphocyte-associated antigen 8) (CTLA-8)
  • 基因序列：NCBI_Gene: 301289
  • 蛋白序列：

大鼠 Rat Il17a 靶点分子功能（预测）

Predicted to enable protein heterodimerization activity and protein homodimerization activity. Involved in several processes, including cellular response to glucocorticoid stimulus; positive regulation of necrotic cell death; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and extracellular space. Used to study anti-basement membrane glomerulonephritis; congestive heart failure; myocarditis; pleurisy; and uveitis. Biomarker of several diseases, including acute necrotizing pancreatitis; inflammatory bowel disease (multiple); lipoid nephrosis; lung disease (multiple); and periodontal disease (multiple). Human ortholog(s) of this gene implicated in Mycobacterium avium complex disease; autoimmune disease (multiple); bronchial disease (multiple); macular degeneration; and rhinitis (multiple). Orthologous to human IL17A (interleukin 17A).

IL17A 分子产品列表

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