EK2103

Mouse RAGE ELISA Kit检测试剂盒（酶联免疫吸附法）

¥2,000.00 – ¥3,400.00

分子靶点：AGER, RAGE
种属：小鼠 (Mouse)
样本类型：血清，血浆，细胞培养上清及其他生物学样本
检测样本体积：20 μL
灵敏度：7.90 pg/mL
检测范围：15.63 pg/mL - 1000 pg/mL
回收率：97% - 125%

在售SKU:70-EK2103-48, 70-EK2103-96

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库存号

描述

文章目录[隐藏]

分子信息
AGER 分子靶点信息概述
AGER 分子靶点综述
- 小鼠 Mouse Ager 分子靶点信息
- 小鼠 Mouse Ager 靶点分子功能（预测）

商品名	Mouse RAGE ELISA Kit (小鼠晚期糖基化终末产物受体 (RAGE) ELISA试剂盒)
检测方法	双抗夹心法
精密度	板内变异系数：2.0% - 3.4%；板间变异系数：2.2% - 4.8%
样本类型	血清，血浆，细胞培养上清及其他生物学样本
检测样本体积	20 μL
灵敏度	7.90 pg/mL
检测范围	15.63 pg/mL - 1000 pg/mL
回收率	97% - 125%
平均回收率	1.05
板式	96孔板，可拆
保存	试剂盒未拆开，4℃保存。已拆开，标准品-20℃保存，其它4℃保存。
运输条件	4℃蓝冰运输
组分	包被抗RAGE单克隆抗体的96孔聚苯乙烯酶标板小鼠RAGE冻干标准品 RAGE检测抗体标准品稀释液检测缓冲液(10×) 底物(TMB) 终止液洗液(22×) 封板膜

检测原理：本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗小鼠RAGE抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本和生物素化的检测抗体，经过孵育，样本中存在的RAGE与固相抗体和检测抗体结合。洗涤去除未结合的物质后，加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中RAGE的浓度成正比。加入终止液终止反应，在450 nm波长(参考波长570 - 630 nm)测定吸光度值。

Mouse RAGE ELISA Kit (小鼠晚期糖基化终末产物受体 (RAGE) ELISA试剂盒) - 标准曲线 — 标准曲线

分子信息

概述小鼠 AGER, RAGE 靶点信息

AGER 分子靶点信息概述

分子名：AGER, advanced glycosylation end-product specific receptor
基因家族：C2-set domain containing; Scavenger receptors
别名：RAGE; SCARJ1; sRAGE
全称：receptor for advanced glycation end-products

AGER 分子靶点综述

晚期糖基化终末产物受体 (RAGE)是35 kDa的免疫球超家族跨膜受体，其名字来自于与晚期糖基化终末产物结合的能力。鉴于其在先天免疫的炎症功能和通过共同基序识别一类配体的能力，RAGE通常被认为是一类识别受体。RAGE与一些慢性疾病有关，如动脉粥样硬化、末梢血管疾病、心肌梗死、充血性心力衰竭、糖尿病、阿尔茨海默病等。与其它组织相比，RAGE在肺部表达量最高，尤其是在I型肺泡上皮细胞，而在特发性肺纤维化 (IPF)中不表达，这表明RAGE在肺系中的表达和调控与心血管系统中不同。阻断/敲除RAGE会导致细胞黏附受损，增加细胞增殖和迁移。

小鼠 Mouse Ager 分子靶点信息

分子名：Ager, advanced glycosylation end product-specific receptor
别称：
- RAGE
基因序列：NCBI_Gene: 11596
蛋白序列：

小鼠 Mouse Ager 靶点分子功能（预测）

Enables S100 protein binding activity; advanced glycation end-product binding activity; and heparin binding activity. Involved in several processes, including cellular response to amyloid-beta; negative regulation of long-term synaptic potentiation; and positive regulation of cytokine production. Acts upstream of or within several processes, including induction of positive chemotaxis; negative regulation of advanced glycation end-product receptor activity; and positive regulation of macromolecule metabolic process. Located in extracellular space and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and lung. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cardiovascular system disease (multiple); cystic fibrosis; kidney failure (multiple); and lupus nephritis. Orthologous to human AGER (advanced glycosylation end-product specific receptor).