Human IL-6 Standard (人白介素6 标准品)

IL6 分子靶点信息概述

• 分子名：IL6, interleukin 6
• 基因家族：Interferons; Interleukins; Interleukin 6 type cytokine family
• 别名：IL-6; BSF2; HGF; HSF
• 曾用名：IFNB2
• 全称：interferon, beta 2; interleukin 6 (interferon, beta 2)

IL6 分子靶点综述

白细胞介素6(IL-6)是一种同时具备促炎性和抗炎性的细胞因子。在人类中，它由IL-6基因编码。在感染期间和受到外伤后，尤其是烧伤或其它组织损伤导致的炎症，IL-6会由T细胞和巨噬细胞分泌，促进免疫应答。研究表明，小鼠抵抗肺炎链球菌感染时需要IL-6的参与，说明IL-6在抵抗感染中发挥作用。IL-6在很多疾病如糖尿病、动脉粥样硬化、抑郁症、阿尔茨海默氏病、系统性红斑狼疮、多发性骨髓瘤、前列腺癌、白塞氏病和类风湿性关节炎等中可促进炎性和自身免疫疾病进程。晚期/转移性癌症患者的血液中具有较高水平的IL-6。

人 Human IL6 分子靶点信息

• 分子名：IL6, interleukin 6
• 别称：
  • B cell stimulatory factor-2
  • B-cell differentiation factor
  • B-cell stimulatory factor 2
  • BSF-2
  • BSF2
  • CDF
  • CTL differentiation factor
  • HGF
  • HSF
  • hybridoma growth factor
  • IFN-beta-2
  • IFNB2
  • IL-6
  • interferon beta-2
  • interferon, beta 2
  • interleukin BSF-2
  • interleukin-6
• 基因序列：NCBI_Gene: 3569
• 蛋白序列：UniProtKB: P05231

人 Human IL6靶点分子功能（预测）

Enables cytokine activity and growth factor activity. Contributes to interleukin-6 receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of macromolecule metabolic process; and regulation of peptide hormone secretion. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; positive regulation of leukocyte adhesion to vascular endothelial cell; and positive regulation of macromolecule metabolic process. Located in extracellular space. Part of interleukin-6 receptor complex. Implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); glucose metabolism disease (multiple); and periodontal disease (multiple). Biomarker of several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); glucose metabolism disease (multiple); and lung disease (multiple).