EK1126

Human Galectin-3 ELISA Kit检测试剂盒（酶联免疫吸附法）

¥1,600.00 – ¥2,650.00

分子靶点：LGALS3, MAC-2, LGALS2
种属：人 (Human)
样本类型：血清，血浆，细胞培养上清及其他生物学样本
检测样本体积：100 μL
灵敏度：2.46 pg/mL
检测范围：62.5 pg/mL - 4000 pg/mL
回收率：85% - 105%

在售SKU:70-EK1126-48, 70-EK1126-96

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文章目录[隐藏]

分子信息
LGALS3 分子靶点信息概述
LGALS3 分子靶点综述
- 人 Human LGALS3 分子靶点信息
- 人 Human LGALS3靶点分子功能（预测）

商品名	Human Galectin-3 ELISA Kit (人半乳糖凝集素-3 ELISA试剂盒)
检测方法	双抗夹心法
精密度	板内变异系数：1.7% - 3.5%；板间变异系数：3.9% - 4.9%
样本类型	血清，血浆，细胞培养上清及其他生物学样本
检测样本体积	100 μL
灵敏度	2.46 pg/mL
检测范围	62.5 pg/mL - 4000 pg/mL
回收率	85% - 105%
平均回收率	0.91
板式	96孔板，可拆
保存	试剂盒未拆开，4℃保存。已拆开，标准品-20℃保存，其它4℃保存。
运输条件	4℃蓝冰运输
组分	包被抗Galectin-3A单克隆抗体的96孔聚苯乙烯酶标板人Galectin-3A冻干标准品 Galectin-3A检测抗体标准品稀释液检测缓冲液(10×) 底物(TMB) 终止液洗液(20×) 封板膜

检测原理：本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗人Galectin-3抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本和生物素化的检测抗体，经过孵育，样本中存在的Galectin-3与固相抗体和检测抗体结合。洗涤去除未结合的物质后，加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中Galectin-3的浓度成正比。加入终止液终止反应，在450 nm波长(参考波长570 - 630 nm)测定吸光度值。

Human Galectin-3 ELISA Kit (人半乳糖凝集素-3 ELISA试剂盒) - 标准曲线 — 标准曲线

分子信息

概述人 LGALS3, MAC-2, LGALS2 靶点信息

LGALS3 分子靶点信息概述

分子名：LGALS3, galectin 3
基因家族：Receptor ligands; Galectins
别名：MAC-2; GALIG
曾用名：LGALS2
全称：advanced glycation end-product receptor 3; lectin, galactoside-binding, soluble, 3

LGALS3 分子靶点综述

半乳糖凝集素-3(Galectin-3)属于凝集素家族，表达于胞核、胞质、线粒体、细胞表面和胞外。Galectin-3对β-半乳糖苷酶具有亲和力，并展示其抗细菌和真菌的活性。它参与很多生物学过程，如细胞黏附、细胞活化和趋化作用、细胞生长和分化、细胞周期以及凋亡等。基于其广泛的生物学功能，Galectin-3被认为与癌症、炎症和纤维化、心脏疾病、中风等有关。Galectin-3表达水平与各种类型的纤维化有关联。在肝脏纤维化、肾脏纤维化以及特发性肺纤维化(IPF)中，Galectin-3的表达上调。在急性失代偿性心力衰竭和慢性心力衰竭人群中，高表达的Galectin-3会导致更高的死亡风险。同时，Galectin-3被认为在肿瘤转移中具有重要作用。

人 Human LGALS3 分子靶点信息

分子名：LGALS3, galectin 3
别称：
- 35 kDa lectin
- advanced glycation end-product receptor 3
- carbohydrate-binding protein 35
- CBP35
- GAL3
- galactose-specific lectin 3
- GALBP
- galectin-3
- GALIG
- IgE-binding protein
- L31
- laminin-binding protein
- lectin L-29
- lectin, galactose binding, soluble 3
- lectin, galactoside binding soluble 3
- lectin, galactoside-binding, soluble, 3
- LGALS2
- MAC-2 antigen
- MAC2
基因序列：NCBI_Gene: 3958
蛋白序列：UniProtKB: P17931

人 Human LGALS3靶点分子功能（预测）

Enables several functions, including IgE binding activity; chemoattractant activity; and laminin binding activity. Involved in several processes, including leukocyte chemotaxis; positive regulation of protein localization to plasma membrane; and regulation of apoptotic process. Located in immunological synapse; mitochondrial inner membrane; and nucleus. Is active in extracellular space. Colocalizes with collagen-containing extracellular matrix. Implicated in asthma. Biomarker of aortic valve stenosis and liver cirrhosis.