IL18 靶点信息

IL18 分子靶点信息概述

  • 分子名：IL18, interleukin 18
  • 基因家族：Interleukins
  • 别名：IGIF; IL1F4; IL-1g; IL-18
  • 全称：interferon-gamma-inducing factor; interleukin 18 (interferon-gamma-inducing factor)

IL18 分子靶点综述

白细胞介素18(IL-18)，又名干扰素γ诱导因子，是一种促炎性细胞因子，在人类中由IL18基因编码。IL-18属于IL-1超家族，由巨噬细胞和其它细胞分泌产生。IL-18刺激后，自然杀伤细胞(NK)和某些T细胞就会释放另一种重要的细胞因子—干扰素γ或Ⅱ型干扰素，进而激活巨噬细胞或其它细胞。IL-18可诱导产生严重的炎症反应，同样可增加人类神经元中β-淀粉样蛋白(与阿尔茨海默氏病相关)的产生。

IL18, interleukin 18 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IL18 分子靶点信息

  • 分子名：IL18, interleukin 18
  • 别称：
    • iboctadekin
    • IFN-gamma-inducing factor
    • IGIF
    • IL-1 gamma
    • IL-18
    • IL-1g
    • IL1F4
    • interferon gamma-inducing factor
    • interleukin 18 (interferon-gamma-inducing factor)
    • interleukin-1 gamma
    • interleukin-18
    • MGC12320
  • 基因序列：NCBI_Gene: 3606
  • 蛋白序列：UniProtKB: Q14116

人 Human IL18靶点分子功能（预测）

Enables cytokine activity and interleukin-18 receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of intracellular signal transduction; and positive regulation of macromolecule metabolic process. Located in extracellular space. Implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Biomarker of several diseases, including autoimmune disease (multiple); cholestasis (multiple); liver disease (multiple); lung disease (multiple); and myositis (multiple).

小鼠 Mouse Il18 分子靶点信息

小鼠 Mouse Il18 靶点分子功能（预测）

Enables cytokine activity. Involved in lipid homeostasis; positive regulation of cell differentiation; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including interleukin-18-mediated signaling pathway; positive regulation of NIK/NF-kappaB signaling; and positive regulation of interferon-gamma production. Located in extracellular space. Is expressed in several structures, including back skin; dorsal aorta; gut; lymphatic system; and reproductive system. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Orthologous to human IL18 (interleukin 18).

大鼠 Rat Il18 分子靶点信息

  • 分子名：Il18, interleukin 18
  • 别称：
    • IFN-gamma-inducing factor
    • IL-1 gamma
    • IL-18
    • interferon gamma-inducing factor
    • interferon-gamma-inducing factor
    • interleukin-1 gamma
    • interleukin-18
  • 基因序列：NCBI_Gene: 29197
  • 蛋白序列：

大鼠 Rat Il18 靶点分子功能（预测）

Predicted to enable cytokine activity and interleukin-18 receptor binding activity. Involved in several processes, including cellular response to hormone stimulus; positive regulation of cell population proliferation; and positive regulation of cytokine production. Located in apical plasma membrane; cytoplasm; and extracellular space. Used to study brain edema; fatty liver disease; heart disease; status epilepticus; and vasculitis. Biomarker of several diseases, including cardiac arrest; ischemia (multiple); lung disease (multiple); perinatal necrotizing enterocolitis; and urinary tract infection. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Orthologous to human IL18 (interleukin 18).

IL18 分子产品列表

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