PDCD1 靶点信息

PDCD1 分子靶点信息概述

  • 分子名：PDCD1, programmed cell death 1
  • 基因家族：CD molecules; V-set domain containing
  • 别名：CD279; PD1; hSLE1; PD-1
  • 曾用名：SLEB2
  • 全称：systemic lupus erythematosus susceptibility 2

PDCD1 分子靶点综述

CD279，又名程序性细胞死亡蛋白1(PD-1)，由PDCD1基因编码。PD1为免疫球蛋白超家族成员，与CD28、CTLA-4和ICOS分子同属于CD28超家族，主要以单体形式表达于活化的CD4+T和CD8+T细胞及B细胞，其配体B7-H1和B7-DC。研究证实，增强PD-1的信号可以下调已活化的T、B细胞在外周组织中的应答，在维持外周T、B细胞耐受中发挥重要的作用。

PDCD1, programmed cell death 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human PDCD1 分子靶点信息

  • 分子名：PDCD1, programmed cell death 1
  • 别称：
    • CD279
    • hPD-1
    • hPD-l
    • hSLE1
    • PD-1
    • PD1
    • programmed cell death protein 1
    • SLEB2
    • systemic lupus erythematosus susceptibility 2
  • 基因序列：NCBI_Gene: 5133
  • 蛋白序列：UniProtKB: Q15116

人 Human PDCD1靶点分子功能（预测）

Involved in positive regulation of T cell apoptotic process. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Implicated in autoimmune disease (multiple); hepatitis B; hepatitis C; hepatocellular carcinoma; and lupus nephritis. Biomarker of several diseases, including Cryptococcal meningitis; anogenital venereal wart; cervix uteri carcinoma in situ; liver disease (multiple); and tuberculosis (multiple).

小鼠 Mouse Pdcd1 分子靶点信息

小鼠 Mouse Pdcd1 靶点分子功能（预测）

Involved in negative regulation of immune response. Acts upstream of or within negative regulation of apoptotic process; negative regulation of tolerance induction; and positive regulation of apoptotic process. Located in external side of plasma membrane. Is expressed in retina. Used to study dilated cardiomyopathy and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); hepatitis B; hepatitis C; hepatocellular carcinoma; and lupus nephritis. Orthologous to human PDCD1 (programmed cell death 1).

大鼠 Rat Pdcd1 分子靶点信息

  • 分子名：Pdcd1, programmed cell death 1
  • 别称：
    • LOC102550808
    • LOC301626
    • programmed cell death protein 1
    • programmed cell death protein 1-like
  • 基因序列：NCBI_Gene: 301626
  • 蛋白序列：UniProtKB: D3ZIN8

大鼠 Rat Pdcd1 靶点分子功能（预测）

Predicted to be involved in negative regulation of immune response and positive regulation of T cell apoptotic process. Predicted to act upstream of or within negative regulation of apoptotic process; negative regulation of tolerance induction; and positive regulation of apoptotic process. Located in plasma membrane. Biomarker of anti-basement membrane glomerulonephritis; periodontitis; and pre-eclampsia. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); hepatitis B; hepatitis C; hepatocellular carcinoma; and lupus nephritis. Orthologous to human PDCD1 (programmed cell death 1).

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