FOXP3 靶点信息

FOXP3 分子靶点信息概述

  • 分子名：FOXP3, forkhead box P3
  • 基因家族：Forkhead boxes
  • 别名：JM2; XPID; AIID; PIDX; DIETER; SCURFIN
  • 曾用名：IPEX
  • 全称：immune dysregulation, polyendocrinopathy, enteropathy, X-linked

FOXP3 分子靶点综述

FoxP3蛋白是转录因子叉头家族的成员之一，表达于调节性T细胞(Regulatory T Cells, Treg)，其发育和功能受到叉头蛋白的影响。T细胞中FoxP3的异常表达会抑制其活性和细胞因子分泌。

FOXP3, forkhead box P3 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human FOXP3 分子靶点信息

  • 分子名：FOXP3, forkhead box P3
  • 别称：
    • AIID
    • DIETER
    • forkhead box protein P3
    • FOXP3delta7
    • immune dysregulation, polyendocrinopathy, enteropathy, X-linked
    • immunodeficiency, polyendocrinopathy, enteropathy, X-linked
    • IPEX
    • JM2
    • MGC141961
    • MGC141963
    • PIDX
    • scurfin
    • XPID
  • 基因序列：NCBI_Gene: 50943
  • 蛋白序列：UniProtKB: Q9BZS1

人 Human FOXP3靶点分子功能（预测）

Enables several functions, including NFAT protein binding activity; enzyme binding activity; and protein homodimerization activity. Involved in several processes, including negative regulation of T cell activation; regulation of gene expression; and regulation of histone modification. Located in cytoplasm and nucleoplasm. Implicated in Human papillomavirus infectious disease; colorectal cancer; immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome; pulmonary tuberculosis; and type 1 diabetes mellitus. Biomarker of several diseases, including adult T-cell leukemia; anogenital venereal wart; chlamydia; liver disease (multiple); and tuberculosis (multiple).

小鼠 Mouse Foxp3 分子靶点信息

小鼠 Mouse Foxp3 靶点分子功能（预测）

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and transcription corepressor activity. Involved in negative regulation of interferon-gamma production; negative regulation of interleukin-17 production; and regulation of T cell anergy. Acts upstream of or within several processes, including positive regulation of T cell tolerance induction; regulation of T cell activation; and regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in central nervous system; genitourinary system; hemolymphoid system; and retina. Used to study Wiskott-Aldrich syndrome and immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome. Human ortholog(s) of this gene implicated in Human papillomavirus infectious disease; colorectal cancer; immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome; pulmonary tuberculosis; and type 1 diabetes mellitus. Orthologous to human FOXP3 (forkhead box P3).

大鼠 Rat Foxp3 分子靶点信息

大鼠 Rat Foxp3 靶点分子功能（预测）

Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; NFAT protein binding activity; and enzyme binding activity. Involved in several processes, including establishment of endothelial blood-brain barrier; negative regulation of defense response to virus; and response to rapamycin. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Used to study intrahepatic cholangiocarcinoma. Biomarker of Korean hemorrhagic fever; asthma; bronchiolitis obliterans; hypertension; and hypothyroidism. Human ortholog(s) of this gene implicated in Human papillomavirus infectious disease; colorectal cancer; immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome; pulmonary tuberculosis; and type 1 diabetes mellitus. Orthologous to human FOXP3 (forkhead box P3).

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