SOD1 靶点信息

SOD1 分子靶点信息概述

  • 分子名：SOD1, superoxide dismutase 1
  • 基因家族：Superoxide dismutases
  • 曾用名：IPOA
  • 别名：ALS; ALS1
  • 全称：amyotrophic lateral sclerosis 1 (adult); superoxide dismutase 1, soluble 

SOD1 分子靶点综述

超氧化物歧化酶(Superoxide Dismutase, SOD1)是一种新型酶制剂。它在生物界的分布极广，几乎从动物到植物，甚至从人到单细胞生物，都有它的存在。SOD1属于Cu-Zn超氧化物歧化酶家族。它结合铜和锌离子，是两种同工酶之一，负责清除体内的自由超氧自由基。其编码的同工酶是一种可溶的细胞质蛋白，以同型二聚体的形式将自然产生但有害的超氧化物自由基转化为分子氧和过氧化氢。这个基因的突变被认为是家族性肌萎缩侧索硬化的原因。

SOD1, superoxide dismutase 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human SOD1 分子靶点信息

  • 分子名：SOD1, superoxide dismutase 1
  • 别称：
    • ALS
    • ALS1
    • Cu/Zn superoxide dismutase
    • epididymis secretory protein Li 44
    • HEL-S-44
    • homodimer
    • hSod1
    • indophenoloxidase A
    • IPOA
    • SOD
    • SOD, soluble
    • STAHP
    • superoxide dismutase
    • superoxide dismutase [Cu-Zn]
    • superoxide dismutase 1, soluble
    • superoxide dismutase, cystolic
  • 基因序列：NCBI_Gene: 6647
  • 蛋白序列：UniProtKB: P00441

人 Human SOD1靶点分子功能（预测）

Enables several functions, including enzyme binding activity; superoxide dismutase activity; and transition metal ion binding activity. Involved in several processes, including hydrogen peroxide biosynthetic process; negative regulation of cholesterol biosynthetic process; and positive regulation of superoxide anion generation. Located in several cellular components, including dendrite cytoplasm; neuronal cell body; and peroxisome. Part of protein-containing complex. Colocalizes with plasma membrane. Implicated in several diseases, including Down syndrome; artery disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and neurodegenerative disease (multiple). Biomarker of several diseases, including Behcet's disease; artery disease (multiple); cutaneous leishmaniasis; eye disease (multiple); and neurodegenerative disease (multiple).

小鼠 Mouse Sod1 分子靶点信息

  • 分子名：Sod1, superoxide dismutase 1, soluble
  • 别称：
    • B430204E11Rik
    • Cu(2+)-Zn2+ superoxide dismutase
    • Cu/Zn-SOD
    • CuZnSOD
    • indophenol oxidase
    • Ipo-1
    • Ipo1
    • RIKEN cDNA B430204E11 gene
    • Sod-1
    • SODC
  • 基因序列：NCBI_Gene: 20655
  • 蛋白序列：

小鼠 Mouse Sod1 靶点分子功能（预测）

Enables superoxide dismutase activity. Involved in axonal transport; negative regulation of inflammatory response; and positive regulation of phagocytosis. Acts upstream of or within several processes, including action potential initiation; determination of adult lifespan; and neurogenesis. Located in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study amyotrophic lateral sclerosis type 1; dry eye syndrome; and low tension glaucoma. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; artery disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and neurodegenerative disease (multiple). Orthologous to human SOD1 (superoxide dismutase 1).

大鼠 Rat Sod1 分子靶点信息

  • 分子名：Sod1, superoxide dismutase 1
  • 别称：
    • CuZnSOD
    • Superoxide dimutase 1 soluble
    • superoxide dismutase
    • superoxide dismutase [Cu-Zn]
    • Superoxide dismutase 1 soluble
    • superoxide dismutase 1, soluble
  • 基因序列：NCBI_Gene: 24786
  • 蛋白序列：

大鼠 Rat Sod1 靶点分子功能（预测）

Enables copper ion binding activity; protein phosphatase 2B binding activity; and superoxide dismutase activity. Involved in several processes, including cellular response to metal ion; hydrogen peroxide biosynthetic process; and removal of superoxide radicals. Located in several cellular components, including dense core granule; neuronal cell body; and peroxisome. Part of protein-containing complex. Used to study hyperthyroidism; hypothyroidism; middle cerebral artery infarction; and sciatic neuropathy. Biomarker of several diseases, including artery disease (multiple); congenital diaphragmatic hernia; middle cerebral artery infarction; non-alcoholic steatohepatitis; and ocular hypertension. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; artery disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and neurodegenerative disease (multiple). Orthologous to human SOD1 (superoxide dismutase 1).

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