PRG2 靶点信息

PRG2 分子靶点信息概述

  • 分子名：PRG2, proteoglycan 2, pro eosinophil major basic protein
  • 基因家族：C-type lectin domain containing
  • 曾用名：proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
  • 别名：MBP; BMPG; proMBP
  • 全称：eosinophil major basic protein

PRG2 分子靶点综述

蛋白多糖 2 (Proteoglycan 2, PRG2)，也叫骨髓蛋白多糖（Bone marrow proteoglycan）、嗜酸性粒细胞颗粒关键碱性蛋白（pro eosinophil major basic protein）等。该基因编码的 PRG2 蛋白质是嗜酸性粒细胞颗粒结晶核心的主要成分。这种蛋白质的高水平前体也存在于胎盘和妊娠血清中，它与几种其他蛋白质形成复合物，包括妊娠相关血浆蛋白 A (pregnancy-associated plasma protein A, PAPPA)、血管紧张素原 (angiotensinogen, AGT) 和 C3dg。该蛋白可能作为细胞毒素和蠕虫毒素参与抗寄生虫防御机制，以及免疫超敏反应。该编码的蛋白质含有一种肽，对革兰氏阳性细菌、革兰氏阴性细菌和真菌表现出有效的抗菌活性。它直接涉及过敏性疾病中的上皮细胞损伤、剥脱和支气管痉挛。已发现该基因编码不同亚型的选择性剪接转录物变体。

PRG2, proteoglycan 2, pro eosinophil major basic protein 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human PRG2 分子靶点信息

  • 分子名：PRG2, proteoglycan 2, pro eosinophil major basic protein
  • 别称：
    • BMPG
    • bone marrow proteoglycan
    • bone-marrow proteoglycan
    • eosinophil granule major basic protein
    • eosinophil major basic protein
    • MBP
    • MBP1
    • MGC14537
    • natural killer cell activator
    • proMBP
    • proteoglycan 2 preproprotein
    • proteoglycan 2, bone marrow
    • proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
  • 基因序列：NCBI_Gene: 5553
  • 蛋白序列：UniProtKB: P13727

人 Human PRG2靶点分子功能（预测）

An extracellular matrix structural constituent conferring compression resistance. Predicted to be involved in defense response to bacterium and immune response. Predicted to act upstream of or within defense response to nematode and regulation of cytokine production. Located in collagen-containing extracellular matrix and extracellular exosome. Biomarker of Chagas disease; asthma; and peritoneum cancer.

小鼠 Mouse Prg2 分子靶点信息

小鼠 Mouse Prg2 靶点分子功能（预测）

Predicted to enable carbohydrate binding activity. Predicted to be an extracellular matrix structural constituent conferring compression resistance. Acts upstream of or within defense response to nematode and regulation of cytokine production. Located in collagen-containing extracellular matrix. Is expressed in several structures, including immune system; liver; lung; and male reproductive gland or organ. Orthologous to human PRG2 (proteoglycan 2, pro eosinophil major basic protein).

大鼠 Rat Prg2 分子靶点信息

  • 分子名：Prg2, proteoglycan 2, bone marrow
  • 别称：
    • BMPG
    • bone marrow proteoglycan
    • eosinophil major basic protein
    • proteoglycan 2
    • proteoglycan 2, bone marrow
  • 基因序列：NCBI_Gene: 58826
  • 蛋白序列：

大鼠 Rat Prg2 靶点分子功能（预测）

Predicted to enable carbohydrate binding activity. Predicted to be involved in defense response to bacterium and immune response. Predicted to act upstream of or within defense response to nematode and regulation of cytokine production. Predicted to be located in extracellular region. Orthologous to human PRG2 (proteoglycan 2, pro eosinophil major basic protein).

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