MRC1 靶点信息

MRC1 分子靶点信息概述

  • 分子名：MRC1, mannose receptor C-type 1
  • 基因家族：Scavenger receptors; C-type lectin domain containing; CD molecules; MicroRNA protein coding host genes
  • 别名：CLEC13D; CD206; bA541I19.1; CLEC13DL
  • 曾用名：MRC1L1
  • 全称：mannose receptor, C type 1-like 1; mannose receptor, C type 1; macrophage mannose receptor

MRC1 分子靶点综述

CD206又名MSR（甘露糖受体），是一个175kDa的跨膜蛋白。CD206主要表达在树突状细胞和巨噬细胞中，在先天和自适应免疫中发挥作用。CD206也在脑组织中的小胶质细胞和mato细胞中表达。CD206主要参与细胞粘附和宿主防御机制，也有报到CD206和阿尔兹海默症中动脉粥样硬化和淀粉样β沉积发展有关。

MRC1, mannose receptor C-type 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human MRC1 分子靶点信息

  • 分子名：MRC1, mannose receptor C-type 1
  • 别称：
    • bA541I19.1
    • C-type lectin domain family 13 member D
    • C-type lectin domain family 13 member D-like
    • CD206
    • CLEC13D
    • CLEC13DL
    • hMR
    • human mannose receptor
    • macrophage mannose receptor 1
    • macrophage mannose receptor 1-like protein 1
    • mannose receptor, C type 1
    • mannose receptor, C type 1-like 1
    • MGC181940
    • MMR
    • MRC1L1
  • 基因序列：NCBI_Gene: 4360
  • 蛋白序列：UniProtKB: P22897

人 Human MRC1 靶点分子功能（预测）

Enables cargo receptor activity. Involved in receptor-mediated endocytosis. Located in endosome membrane and plasma membrane.

小鼠 Mouse Mrc1 分子靶点信息

小鼠 Mouse Cd55 靶点分子功能（预测）

Enables mannose binding activity and transmembrane signaling receptor activity. Acts upstream of or within cellular response to interleukin-4; cellular response to lipopolysaccharide; and cellular response to type II interferon. Located in cell surface. Is expressed in several structures, including hemolymphoid system; intestine; liver; lung; and yolk sac. Orthologous to human MRC1 (mannose receptor C-type 1).

大鼠 Rat Mrc1 分子靶点信息

大鼠 Rat Mrc1 靶点分子功能（预测）

Predicted to enable cargo receptor activity; mannose binding activity; and transmembrane signaling receptor activity. Predicted to be involved in receptor-mediated endocytosis. Predicted to act upstream of or within cellular response to interleukin-4; cellular response to lipopolysaccharide; and cellular response to type II interferon. Predicted to be located in cell surface and endosome membrane. Predicted to be active in plasma membrane. Orthologous to human MRC1 (mannose receptor C-type 1).

MRC1 分子产品列表

MRC1 分子靶点最新资讯

肿瘤免疫治疗新策略 | 利用装载药物的大肠杆菌结合ICD极化肿瘤相关巨噬细胞 

极化巨噬细胞以降低肿瘤对PD-1免疫疗法的耐受性