CRP 靶点信息

CRP 分子靶点信息概述

  • 分子名：CRP, C-reactive protein
  • 基因家族：Short pentraxins
  • 别名：PTX1
  • 全称：pentraxin 1; C-reactive protein, pentraxin-related

CRP 分子靶点综述

C-反应蛋白(CRP)是在血浆中发现的一种环状、五聚体蛋白。肝脏对巨噬细胞和脂肪细胞释放的因子产生应答后可合成CRP。CRP是一种肝源性的急性蛋白，在巨噬细胞和T细胞分泌白介素6后增加，其生理作用是与死细胞或濒死细胞(和某些类型的细菌)表面的溶血磷脂胆碱结合，以通过C1Q复合物来激活补体系统。它与C-肽(胰岛素)或蛋白C(血凝)不相关。CRP通常作为炎症标志物，当机体受到炎症感染时，CRP水平会上升。最近的研究表明，患者具有较高基础水平的CRP，通常伴随着一个较高糖尿病、高血压和心血管疾病的发生率。

CRP, C-reactive protein 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CRP 分子靶点信息

  • 分子名：CRP, C-reactive protein
  • 别称：
    • C-reactive protein, pentraxin-related
    • c-reactive protein, petaxin related
    • MGC149895
    • MGC88244
    • pentraxin 1
    • PTX1
  • 基因序列：NCBI_Gene: 1401
  • 蛋白序列：UniProtKB: P02741

人 Human CRP靶点分子功能（预测）

Enables several functions, including complement component C1q complex binding activity; low-density lipoprotein particle binding activity; and low-density lipoprotein particle receptor binding activity. Involved in several processes, including negative regulation of macrophage derived foam cell differentiation; positive regulation of superoxide anion generation; and regulation of gene expression. Acts upstream of or within vasoconstriction. Located in extracellular space. Implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); macular degeneration (multiple); middle cerebral artery infarction; and nephritis (multiple). Biomarker of several diseases, including artery disease (multiple); auditory system disease (multiple); autoimmune disease (multiple); eye disease (multiple); and lung disease (multiple).

小鼠 Mouse Crp 分子靶点信息

小鼠 Mouse Crp 靶点分子功能（预测）

Predicted to enable several functions, including cholesterol binding activity; complement component C1q complex binding activity; and low-density lipoprotein particle binding activity. Predicted to be involved in several processes, including complement activation, classical pathway; regulation of gene expression; and regulation of superoxide anion generation. Predicted to act upstream of or within vasoconstriction. Predicted to be located in filopodium and growth cone. Predicted to be active in extracellular space. Is expressed in embryo and liver. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); macular degeneration (multiple); middle cerebral artery infarction; and nephritis (multiple). Orthologous to human CRP (C-reactive protein).

大鼠 Rat Crp 分子靶点信息

大鼠 Rat Crp 靶点分子功能（预测）

Enables cholesterol binding activity; identical protein binding activity; and low-density lipoprotein particle binding activity. Involved in several processes, including cellular response to nitric oxide; complement activation, classical pathway; and negative regulation of superoxide anion generation. Located in extracellular space; filopodium; and growth cone. Used to study rheumatoid arthritis. Biomarker of several diseases, including acute kidney failure; artery disease (multiple); iron deficiency anemia; obesity; and status epilepticus. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); macular degeneration (multiple); middle cerebral artery infarction; and nephritis (multiple). Orthologous to human CRP (C-reactive protein).

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