COL1A1 分子靶点信息

COL1A1 分子靶点信息概述

  • 分子名：COL1A1, collagen type I alpha 1 chain
  • 基因家族：Collagens
  • 别名：collagen, type I, alpha 1; OI4

COL1A1 分子靶点综述

I 型胶原蛋白是皮肤、骨骼和肌腱等结缔组织中含量最丰富的结构蛋白。它是一种合成的前胶原分子，其特征为 300 nm 的三重螺旋结构域，两侧是球状的 N 端和 c 端前肽。三螺旋结构域包含 Gly-Xaa-Yaa 三联体，其中 Xaa 和 Yaa 通常分别是脯氨酸和羟脯氨酸。前胶原蛋白 N 和 C 蛋白酶活性去除非螺旋前肽，因此成熟的三螺旋可以自组装成胶原原纤维，为组织提供拉伸强度。

COL1A1, collagen type I alpha 1 chain 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human COL1A1 分子靶点信息

  • 分子名：COL1A1, collagen type I alpha 1 chain
  • 别称：
    • alpha-1 type I collagen
    • alpha1(I) procollagen
    • CAFYD
    • collagen alpha 1 chain type I
    • collagen alpha-1(I) chain
    • collagen alpha-1(I) chain preproprotein
    • collagen of skin, tendon and bone, alpha-1 chain
    • collagen type I alpha 1
    • collagen, type I, alpha 1
    • EDSARTH1
    • EDSC
    • OI1
    • OI2
    • OI3
    • OI4
    • pro-alpha-1 collagen type 1
    • type I proalpha 1
    • type I procollagen alpha 1 chain
  • 基因序列：NCBI_Gene: 1277
  • 蛋白序列：UniProtKB: P02452

人 Human COL1A1靶点分子功能（预测）

Enables identical protein binding activity; platelet-derived growth factor binding activity; and protease binding activity. Involved in several processes, including collagen biosynthetic process; collagen fibril organization; and skin morphogenesis. Acts upstream of or within skeletal system development. Located in extracellular space. Part of collagen type I trimer. Colocalizes with collagen-containing extracellular matrix. Implicated in several diseases, including Ehlers-Danlos syndrome arthrochalasia type 1; aggressive periodontitis; bone disease (multiple); cutaneous leishmaniasis; and dentinogenesis imperfecta. Biomarker of several diseases, including alcoholic hepatitis; autoimmune disease (multiple); chronic obstructive pulmonary disease; end stage renal disease; and lupus nephritis.

小鼠 Mouse Col1a1 分子靶点信息

小鼠 Mouse Col1a1 靶点分子功能（预测）

Enables identical protein binding activity. An extracellular matrix structural constituent. Acts upstream of or within several processes, including cellular response to mechanical stimulus; face morphogenesis; and skeletal system morphogenesis. Located in cytoplasm and extracellular matrix. Part of collagen type I trimer. Is expressed in several structures, including alimentary system; embryo mesenchyme; eye; heart and pericardium; and skeleton. Used to study Ehlers-Danlos syndrome and osteogenesis imperfecta (multiple). Human ortholog(s) of this gene implicated in several diseases, including Ehlers-Danlos syndrome arthrochalasia type 1; aggressive periodontitis; bone disease (multiple); cutaneous leishmaniasis; and dentinogenesis imperfecta. Orthologous to human COL1A1 (collagen type I alpha 1 chain).

大鼠 Rat Col1a1 分子靶点信息

  • 分子名：Col1a1, collagen type I alpha 1 chain
  • 别称：
    • alpha-1 type I collagen
    • COLIA1
    • collagen alpha-1(I) chain
    • collagen, type 1, alpha 1
    • collagen, type I, alpha 1
    • procollagen type I alpha 1
    • procollagen type I, alpha 1
    • procollagen, type 1, alpha 1
    • procollagen, type I, alpha 1
    • type I-alpha 1 collagen
  • 基因序列：NCBI_Gene: 29393
  • 蛋白序列：

大鼠 Rat Col1a1 靶点分子功能（预测）

Predicted to enable identical protein binding activity; platelet-derived growth factor binding activity; and protease binding activity. Predicted to be an extracellular matrix structural constituent. Involved in several processes, including cellular response to growth factor stimulus; cellular response to mechanical stimulus; and cellular response to retinoic acid. Acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and secretory granule. Used to study cholestasis and non-alcoholic fatty liver disease. Biomarker of several diseases, including artery disease (multiple); bladder neck obstruction; liver disease (multiple); pulmonary fibrosis; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including Ehlers-Danlos syndrome arthrochalasia type 1; aggressive periodontitis; bone disease (multiple); cutaneous leishmaniasis; and dentinogenesis imperfecta. Orthologous to human COL1A1 (collagen type I alpha 1 chain).

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