CD19 靶点信息

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CD19 分子靶点信息概述

  • 分子名：CD19, CD19 molecule
  • 基因家族：CD molecules; Immunoglobulin like domain containing; Minor histocompatibility antigens
  • 全称：CD19 antigen

CD19 分子靶点综述

CD19 是 95kDa 的跨膜糖蛋白，属于免疫球蛋白超家族的成员，除了浆细胞，表达于B细胞的各个发育阶段。 CD19与CD21、CD81和MHC II类分子形成复合物，通过与B细胞受体作用，起始成熟B细胞的活化。 CD19可促进B细胞增殖、发育和活化，以及记忆性B细胞的成熟。在CD19缺失的小鼠中，骨髓和外周的B细胞生成和成熟受到影响。

CD19, CD19 molecule 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CD19 分子靶点信息

  • 分子名：CD19, CD19 molecule
  • 别称：
    • B-lymphocyte antigen CD19
    • B-lymphocyte surface antigen B4
    • B4
    • cd19 antigen
    • CVID3
    • differentiation antigen CD19
    • MGC12802
    • T-cell surface antigen Leu-12
  • 基因序列：NCBI_Gene: 930
  • 蛋白序列：UniProtKB: P15391

人 Human CD19靶点分子功能（预测）

Involved in several processes, including B cell proliferation involved in immune response; positive regulation of phosphatidylinositol 3-kinase activity; and positive regulation of release of sequestered calcium ion into cytosol. Located in external side of plasma membrane. Is integral component of plasma membrane. Part of protein-containing complex. Implicated in common variable immunodeficiency.

小鼠 Mouse Cd19 分子靶点信息

小鼠 Mouse Cd19 靶点分子功能（预测）

Involved in several processes, including B-1 B cell differentiation; positive regulation of phosphatidylinositol 3-kinase activity; and positive regulation of release of sequestered calcium ion into cytosol. Acts upstream of or within B cell receptor signaling pathway. Located in external side of plasma membrane. Is integral component of plasma membrane. Is expressed in liver and spleen. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human CD19 (CD19 molecule).

大鼠 Rat Cd19 分子靶点信息

大鼠 Rat Cd19 靶点分子功能（预测）

Predicted to be involved in several processes, including B cell activation; B cell receptor signaling pathway; and positive regulation of phosphatidylinositol 3-kinase activity. Predicted to act upstream of or within positive regulation of release of sequestered calcium ion into cytosol. Predicted to be integral component of plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human CD19 (CD19 molecule).

CD19 分子产品列表

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