Mhc Class Ii Peptides Induce Cd8(+)Cd44(+)Ly49(+) Regulatory T Cells in C57bl/6 Mice

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  • 作者：Yao, Y., Wang, X., Zhou, H., Zhang, H., Shi, Y., Wang, S. & Wang, X.
  • 期刊：Cellular immunology 312, 71-77 (2017)
  • 阅读原文

CD8(+) regulatory T cells (Tregs) play an important role in regulating peripheral immune tolerance. However, difficulties in the characterization of CD8(+) Tregs that lack suitable markers have a considerably limited research in this area. Moreover, the induction and effector mechanisms of CD8(+) Tregs remain unclear. Herein, we demonstrate the suitability of Ly49 and CD44 as markers for CD8(+) Tregs. Our data also show that MHC class II restricted peptides induce CD8(+)CD44(+)Ly49(+) Tregs via CD4(+) T cell activation. Furthermore, we also found cross-suppressive activity of these CD8(+) Tregs on responding CD4(+) T cells in a cytotoxicity dependent manner. Our data provide new insights into the induction and function of CD8(+) Tregs.

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