Decreased Expression of Calpain-9 Predicts Unfavorable Prognosis in Patients with Gastric Cancer

  • 类型：
  • 作者：Peng, P., Wu, W., Zhao, J., Song, S., Wang, X., Jia, D., Shao, M., Zhang, M., Li, L., Wang, L., Duan, F., Zhao, R., Yang, C., Wu, H., Zhang, J., Shen, Z., Ruan, Y. & Gu, J.
  • 期刊：Scientific reports 6, 29604 (2016)
  • 阅读原文

Calpain-8 and calpain-9 belong to the family of calcium-dependent cysteine proteases, which are highly expressed in the stomach. However, the roles of calpain-8 and calpain-9 in gastric tumorigenesis remain little understood. Herein, we demonstrated that calpain-9 was generally decreased in gastric cancer cell lines and primary tumor tissues, while calpain-8 expression was not significantly altered. Calpain-9, but not calpain-8, induced cell cycle arrest in the G1 phase and cellular apoptosis in vitro, and it attenuated the growth of subcutaneous tumor xenografts in vivo. Low expression of calpain-9 was positively associated with male sex, late T stage, lymph node metastasis, and advanced TNM stage. Further analysis identified calpain-9 as an independent prognostic factor for poor prognosis, and combining calpain-9 with TNM stage generated a better predictive model for patient outcomes. In conclusion, calpain-9 is a tumor suppressor that can be regarded as a potential prognosis indicator for clinical outcomes in gastric cancer.

文章引用产品