Anti-Breast Cancer Activity of Spg-56 from Sweet Potato in Mcf-7 Bearing Mice in Situ through Promoting Apoptosis and Inhibiting Metastasis

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  • 作者：Li, Z., Yu, Y., Wang, M., Xu, H., Han, B., Jiang, P., Ma, H., Li, Y., Tian, C., Zhou, D., Li, X. & Ye, X.
  • 期刊：Scientific reports 9, 146 (2019)
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SPG-56 is a newly isolated glycoprotein from sweet potatoes (Zhongshu NO. 1), but its value for suppressing breast cancer progression remains unknown. This study was designed to investigate the potential anti-cancer effects of SPG-56, which consists of 2.9% sugar and 97.1% protein. The effects of SPG-56 on the proliferation and apoptosis of breast cancer cells were determined using CCK-8 and Hoechst 33342 assays and flow cytometry, after staining with Annexin V and PI respectively. The activities of SPG-56 against breast cancer were examined using female BALB/c nude mice orthotopically implanted with human breast carcinoma cells of the types MCF-7 and 4T1-Luc. The cellular experiments showed that SPG-56 inhibited proliferation and promoted apoptosis of MCF-7 cells dose- and time-dependently. Oral administration of SPG-56 significantly suppressed the development of MCF-7 tumor cells (P?文章引用产品