Tachypleus Tridentatus Lectin Enhances Oncolytic Vaccinia Virus Replication to Suppress in Vivo Hepatocellular Carcinoma Growth

  • 类型：
  • 作者：Li, G., Cheng, J., Mei, S., Wu, T. & Ye, T.
  • 期刊：Marine drugs 162018)
  • 阅读原文

Lectins play diverse roles in physiological processes as biological recognition molecules. In this report, a gene encoding Tachypleus tridentatus Lectin (TTL) was inserted into an oncolytic vaccinia virus (oncoVV) vector to form oncoVV-TTL, which showed significant antitumor activity in a hepatocellular carcinoma mouse model. Furthermore, TTL enhanced oncoVV replication through suppressing antiviral factors expression such as interferon-inducible protein 16 (IFI16), mitochondrial antiviral signaling protein (MAVS) and interferon-beta (IFN-β). Further investigations revealed that oncoVV-TTL replication was highly dependent on ERK activity. This study might provide insights into a novel way of the utilization of TTL in oncolytic viral therapies.

文章引用产品