TSLP 靶点信息

TSLP 分子靶点信息概述

  • 分子名：TSLP, thymic stromal lymphopoietin

TSLP 分子靶点综述

胸腺基质淋巴细胞生成素(TSLP)主要由非造血细胞如成纤维细胞、上皮细胞和不同类型的基质或基质样细胞产生。它主要影响骨髓细胞、诱导单核细胞释放T细胞虏获趋化因子和增强髓样(CD11c+)树突状细胞成熟。研究表明，TSLP还可激活位于表皮的特定树突状细胞亚群—朗格汉斯细胞的成熟。胸腺TSLP激活髓样和浆细胞样(CD123+)树突状细胞会导致调节性T细胞的产生。TSLP通过胸腺基质淋巴细胞受体CRLF2和IL-7Rα链组成的异源二聚体受体复合物产生信号。结合STAT5后就会诱导其发生磷酸化，进而导致上游转录因子的表达。TSLP的表达与许多疾病包括哮喘、炎症性关节炎、特应性皮炎、湿疹及其它过敏状态有关。

TSLP, thymic stromal lymphopoietin 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human TSLP 分子靶点信息

人 Human TSLP靶点分子功能（预测）

Enables cytokine activity and interleukin-7 receptor binding activity. Involved in several processes, including defense response to other organism; positive regulation of cytokine production; and positive regulation of signal transduction. Located in extracellular region. Biomarker of common cold and respiratory syncytial virus infectious disease.

小鼠 Mouse Tslp 分子靶点信息

小鼠 Mouse Tslp 靶点分子功能（预测）

Enables cytokine activity. Predicted to be involved in several processes, including defense response to other organism; positive regulation of cytokine production; and positive regulation of signal transduction. Predicted to be located in extracellular region. Is expressed in ductus deferens; epididymis; ileum; and testis. Used to study atopic dermatitis; autoimmune hemolytic anemia; cryoglobulinemia; and membranoproliferative glomerulonephritis. Orthologous to human TSLP (thymic stromal lymphopoietin).

大鼠 Rat Tslp 分子靶点信息

大鼠 Rat Tslp 靶点分子功能（预测）

Predicted to enable cytokine activity and interleukin-7 receptor binding activity. Predicted to be involved in several processes, including defense response to other organism; positive regulation of cytokine production; and positive regulation of signal transduction. Predicted to be located in extracellular region. Orthologous to human TSLP (thymic stromal lymphopoietin).

TSLP 分子产品列表

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