IL1RL1 靶点信息

IL1RL1 分子靶点信息概述

  • 分子名：IL1RL1, interleukin 1 receptor like 1
  • 基因家族：I-set domain containing; Interleukin receptors; TIR domain containing
  • 别名：ST2; FIT-1; ST2L; ST2V; DER4; T1; IL33R
  • 全称：homolog of mouse growth stimulation-expressed

IL1RL1 分子靶点综述

致癌抑制因子2(ST2)也称为IL-1R4，是IL-1受体家族糖蛋白成员，可促使Th2免疫应答。ST2表达于肥大细胞、活化的Th2细胞、巨噬细胞和心肌细胞表面。它与具有胞内和胞外活性的促炎性IL-1家族成员IL-33结合。除了其促进肥大细胞和Th2依赖的炎症作用，跨膜ST2的活化可增强炎症相关的反应，保护机体免受动脉粥样硬化和心肌细胞肥大的伤害。血清中可溶性ST2在炎症时的表达水平会升高，包括过敏性哮喘、败血症、创伤、登革热和肺部疾病。血清ST2的升高也受心力衰竭的多方面影响，包括主动脉瓣狭窄、充血性心肌病和心血管衰竭和死亡风险。

IL1RL1, interleukin 1 receptor like 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IL1RL1 分子靶点信息

  • 分子名：IL1RL1, interleukin 1 receptor like 1
  • 别称：
    • DER4
    • FIT-1
    • growth stimulation-expressed
    • homolog of mouse growth stimulation-expressed
    • IL33R
    • interleukin 1 receptor-like 1
    • interleukin 1 receptor-related protein
    • interleukin-1 receptor-like 1
    • MGC32623
    • ST2
    • ST2L
    • ST2V
    • T1
  • 基因序列：NCBI_Gene: 9173
  • 蛋白序列：UniProtKB: Q01638

人 Human IL1RL1靶点分子功能（预测）

Predicted to enable interleukin-33 binding activity and interleukin-33 receptor activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within negative regulation of I-kappaB kinase/NF-kappaB signaling. Located in cytosol; focal adhesion; and plasma membrane. Implicated in asthma and coronary artery disease. Biomarker of several diseases, including Human papillomavirus infectious disease; hemolytic-uremic syndrome; lung disease (multiple); paracoccidioidomycosis; and tongue squamous cell carcinoma.

小鼠 Mouse Il1rl1 分子靶点信息

小鼠 Mouse Il1rl1 靶点分子功能（预测）

Enables interleukin-33 binding activity and interleukin-33 receptor activity. Involved in several processes, including negative regulation of T-helper 1 type immune response; positive regulation of macrophage activation; and regulation of cytokine production. Acts upstream of or within negative regulation of I-kappaB kinase/NF-kappaB signaling. Located in external side of plasma membrane and extracellular matrix. Is expressed in several structures, including immune system; musculoskeletal system; salivary gland; skin; and visual system. Human ortholog(s) of this gene implicated in asthma and coronary artery disease. Orthologous to human IL1RL1 (interleukin 1 receptor like 1).

大鼠 Rat Il1rl1 分子靶点信息

大鼠 Rat Il1rl1 靶点分子功能（预测）

Predicted to enable interleukin-33 binding activity and interleukin-33 receptor activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to peptide; and negative regulation of cell population proliferation. Located in external side of plasma membrane and extracellular space. Biomarker of acute myocardial infarction and bacterial pneumonia. Human ortholog(s) of this gene implicated in asthma and coronary artery disease. Orthologous to human IL1RL1 (interleukin 1 receptor like 1).

IL1RL1 分子产品列表

IL1RL1 分子靶点最新资讯

你知道体液免疫的驱动精灵吗？