GAS6 靶点信息

GAS6 分子靶点信息概述

  • 分子名：GAS6, growth arrest specific 6
  • 基因家族：Gla domain containing
  • 曾用名：AXLLG
  • 别名：AXSF; FLJ34709; DKFZp666G247
  • 全称：AXL receptor tyrosine kinase ligand; AXL stimulatory factor

GAS6 分子靶点综述

Gas6 (生长停滞特异性蛋白6) 是一种分泌蛋白，其氨基末端为富含γ-羧基谷氨酸基的Gla结构域，且依赖于维生素K的活性。Gas6通过受体Axl、Dtk/Tyro3和Mer发出信号，并被游离的可溶性Axl和Mer抑制。Gas6具有保护细胞免受应激诱导的凋亡，促进凋亡细胞碎片的吞噬，促进血小板活化，抑制炎性细胞因子的产生，抑制VEGF诱导的血管生成，调节肿瘤细胞的扩散等多种作用。

GAS6, growth arrest specific 6 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human GAS6 分子靶点信息

  • 分子名：GAS6, growth arrest specific 6
  • 别称：
    • AXL receptor tyrosine kinase ligand
    • AXL stimulatory factor
    • AXLLG
    • AXSF
    • DKFZp666G247
    • FLJ34709
    • GAS-6
    • growth arrest-specific 6
    • growth arrest-specific protein 6
  • 基因序列：NCBI_Gene: 2621
  • 蛋白序列：UniProtKB: Q14393

人 Human GAS6靶点分子功能（预测）

Enables several functions, including cysteine-type endopeptidase inhibitor activity involved in apoptotic process; phosphatidylserine binding activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of apoptotic process; regulation of gene expression; and regulation of signal transduction. Acts upstream of or within positive regulation of ERK1 and ERK2 cascade and positive regulation of fibroblast proliferation. Located in cytoplasm and extracellular space.

小鼠 Mouse Gas6 分子靶点信息

小鼠 Mouse Gas6 靶点分子功能（预测）

Enables receptor ligand activity. Involved in negative regulation of apoptotic process. Acts upstream of or within several processes, including blood coagulation; negative regulation of apoptotic process; and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in extracellular space. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and limb. Orthologous to human GAS6 (growth arrest specific 6).

大鼠 Rat Gas6 分子靶点信息

  • 分子名：Gas6, growth arrest specific 6
  • 别称：
    • AXL receptor tyrosine kinase ligand
    • GAS-6
    • GPF
    • growth arrest-specific protein 6
    • growth-potentiating factor
  • 基因序列：NCBI_Gene: 58935
  • 蛋白序列：

大鼠 Rat Gas6 靶点分子功能（预测）

Predicted to enable several functions, including cysteine-type endopeptidase inhibitor activity involved in apoptotic process; phosphatidylserine binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to glucose stimulus; positive regulation of intracellular signal transduction; and regulation of renal system process. Located in extracellular space. Used to study glomerulonephritis. Orthologous to human GAS6 (growth arrest specific 6).

GAS6 分子产品列表

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