FGFR2 靶点信息

FGFR2 分子靶点信息概述

  • 分子名：FGFR2, fibroblast growth factor receptor 2
  • 基因家族：I-set domain containing; Receptor tyrosine kinases; CD molecules
  • 别名：CEK3; TK14; TK25; ECT1; K-SAM; CD332
  • 曾用名：KGFR; BEK; CFD1; JWS
  • 全称：bacteria-expressed kinase; keratinocyte growth factor receptor; craniofacial dysostosis 1; Jackson-Weiss syndrome;
    Crouzon syndrome; Pfeiffer syndrome

FGFR2 分子靶点综述

成纤维细胞生长因子受体 2 (Fibroblast growth factor receptor 2, FGFR2)是一种酪氨酸激酶受体。该受体目前发现有 FGFR1、FGFR2、FGFR3 和FGFR4，是一种跨膜蛋白质, 分别为细胞外、跨膜部分、胞内近膜区和胞内结构区( 酪氨酸激酶区) , 为配体的特异性结合提供了受体的分子基础。成纤维细胞生长因子受体(Fibroblast growth factor receptors, FGFR）家族，能促进细胞生长、提高 细胞侵袭力和活力以及促进血管新生。其中人成纤维细胞生长因子2 (FGFR2)的表达异常与基因多态性与多种肿瘤相关，如乳腺癌、胆管癌、肺癌等，并且与肿瘤细胞增生、侵袭有关。

FGFR2, fibroblast growth factor receptor 2 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human FGFR2 分子靶点信息

  • 分子名：FGFR2, fibroblast growth factor receptor 2
  • 别称：
    • bacteria-expressed kinase
    • BBDS
    • BEK
    • BEK fibroblast growth factor receptor
    • BFR-1
    • CD332
    • CEK3
    • CFD1
    • ECT1
    • FGF receptor
    • FGFR-2
    • FGFR2-AHCYL1 fusion kinase protein
    • fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome)
    • fibroblast growth factor receptor 2 isoform IgIIIb isoform
    • fibroblast growth factor receptor 2 isoform IgIIIc isoform
    • fibroblast growth factor receptor 2 Ksam IV secreted isoform
    • FLJ98662
    • hydroxyaryl-protein kinase
    • JWS
    • K-SAM
    • keratinocyte growth factor receptor
    • KGFR
    • protein tyrosine kinase, receptor like 14
    • soluble FGFR4 variant 4
    • TK14
    • TK25
  • 基因序列：NCBI_Gene: 2263
  • 蛋白序列：UniProtKB: P21802

人 Human EGFR靶点分子功能（预测）

Enables fibroblast growth factor binding activity; fibroblast growth factor receptor activity; and protein homodimerization activity. Involved in several processes, including embryonic cranial skeleton morphogenesis; negative regulation of keratinocyte proliferation; and protein phosphorylation. Located in cell cortex; cell surface; and nucleus. Is integral component of plasma membrane. Colocalizes with collagen-containing extracellular matrix. Implicated in several diseases, including Beare-Stevenson cutis gyrata syndrome; Jackson-Weiss syndrome; LADD syndrome; gastrointestinal system cancer (multiple); and synostosis (multiple). Biomarker of endometriosis; prostate cancer; squamous cell carcinoma; stomach cancer; and transitional cell carcinoma.

小鼠 Mouse Fgfr2 分子靶点信息

小鼠 Mouse Fgfr2 靶点分子功能（预测）

Enables fibroblast growth factor binding activity. Involved in fibroblast growth factor receptor signaling pathway; forebrain generation of neurons; and positive regulation of cell cycle. Acts upstream of or within several processes, including cardiac chamber morphogenesis; lung development; and morphogenesis of an epithelium. Located in excitatory synapse and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Used to study Beare-Stevenson cutis gyrata syndrome; Crouzon syndrome; Pfeiffer syndrome; acrocephalosyndactylia; and intestinal atresia. Human ortholog(s) of this gene implicated in several diseases, including Beare-Stevenson cutis gyrata syndrome; Jackson-Weiss syndrome; gastrointestinal system cancer (multiple); reproductive organ cancer (multiple); and synostosis (multiple). Orthologous to human FGFR2 (fibroblast growth factor receptor 2).

大鼠 Rat Fgfr2 分子靶点信息

大鼠 Rat Fgfr2 靶点分子功能（预测）

Enables fibroblast growth factor binding activity and fibroblast growth factor receptor activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to retinoic acid; and positive regulation of smooth muscle cell proliferation. Located in cell surface; cytoplasm; and nucleus. Used to study prostate cancer and retinitis pigmentosa. Biomarker of hypospadias. Human ortholog(s) of this gene implicated in several diseases, including Beare-Stevenson cutis gyrata syndrome; Jackson-Weiss syndrome; LADD syndrome; gastrointestinal system cancer (multiple); and synostosis (multiple). Orthologous to human FGFR2 (fibroblast growth factor receptor 2).

FGFR2 分子产品列表

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